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Primary human hepatocytes as a tool for the evaluation of structure-activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin, rifapentine and rifabutin.
In our laboratory, primary human hepatocytes are being investigated as an in vitro experimental system for the evaluation of pharmacokinetic drug-drug interactions. Our study here represents theExpand
Substrates of human hepatic cytochrome P450 3A4.
Cytochrome P450 isozyme 3A4 (CYP3A4) is a major isozyme in the human liver and is known to metabolize a larger variety of xenobiotics and endogenous biochemicals. The identities of CYP3A4 substratesExpand
2,3,7,8 Tetrachlorodibenzo-p-dioxin induction of cytochrome P4501A in cultured rat and human hepatocytes.
We report here a novel observation that 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD) induced predominantly cytochrome P4501A1 (CYP1A1) in rat hepatocytes and predominantly CYP1A2 in human hepatocytes.Expand
Acute surgical emergencies in inflammatory bowel disease.
BACKGROUND Acute surgical emergencies in patients with inflammatory bowel disease may carry a substantial morbidity, but fortunately today, a low mortality. The aim of this review is to delineate theExpand
Analysis of the hemodynamic and ventilatory effects of laparoscopic cholecystectomy.
Laparoscopic cholecystectomy uses carbon dioxide, a highly diffusable gas, for insufflation. With extended periods of insufflation, patient arterial carbon dioxide levels may be adversely altered.Expand
Spectrum of disease and outcome of complicated diverticular disease.
BACKGROUND Diverticular disease is a common entity. The presentation, investigations performed, and management are variable. Our objectives were to assess the presentation, extent of disease, andExpand
Isolation and culturing of hepatocytes from human livers
Using a modified collagenase digestion procedure, we were successful in the isolation of viable hepatocytes from human liver surgical wastes, unused transplantable livers, and diseased livers fromExpand
Ischemic colitis: spectrum of disease and outcome.
BACKGROUND The aim of this study was to identify risk factors, clinical characteristics, and outcome of patients with colon ischemia. METHODS A 10-year (1992-2002) retrospective study wasExpand
The role of prostanoids in the production of acute acalculous cholecystitis by platelet-activating factor.
Gallbladder tissue from patients with acute acalculous cholecystitis contains increased amounts of prostanoids when compared to normal gallbladder tissue. Platelet-activating factor (PAF) is a potentExpand
Management and outcome of patients with combined bile duct and hepatic artery injuries.
BACKGROUND Major bile duct injury is an important therapeutic problem that can be associated with simultaneous injury to the hepatic artery. Limited information exists regarding the course ofExpand