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The Relation of SJögren's Syndrome to Rheumatoid Arthritis
Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation.
- O. Sedláček, M. Hrubý, +5 authors K. Ulbrich
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 July 2012
Five 9-anilinoacridine-type drugs and their conjugates are synthesized with biocompatible water-soluble hydrazide polymer carrier and retained their in vitro antiproliferative properties. Expand
Double-blind comparison of ibuprofen and phenylbutazone in the short-term treatment of rheumatoid arthritis.
- K. Pavelka, A. Šusta, +4 authors J. Maleček
- Medicine, Chemistry
- Rheumatology and rehabilitation
- 1 May 1973
Alclofenac, a new anti-inflammatory agent, has been assessed comparatively with yhenjdbutazone in a double-blind cross-over study including 92 patients with rheumatoid arthritis, finding that alcl ofenac was statistically superior to phenylbutaz one in improving morning stifness. Expand
The occurrence of adverse side-effects during controlled clinical trials of nonsteroidal antirheumatic agents.
Novel Polymeric Nanoparticles Assembled by Metal Ion Addition
Potentially biodegradable graft polymer core-shell nanoparticles assembling by addition of metal ions intended to be used for radionuclide and drug delivery purposes are described. With Cu2+ ions,… Expand
Cyclotriphosphazene-Based Star Copolymers as Structurally Tunable Nanocarriers with Programmable Biodegradability
Double-blind comparison of alclofenac and phenylbutazone in the short-term treatment of rheumatoid arthritis.
- K. Pavelka, O. Vojtíšek, A. Brémová, D. Kaňková, D. Hándlová
- Current medical research and opinion
A double-blind crossover trial to compare the therapeutic efficacy of a new antirheumatic drug, alclofenac, with that of phenylbutazone in rheumatoid arthritis revealed that the patients improved equally on both drugs but that alcl ofenac was statistically superior to phenyl Butzone in improving morning stiffness. Expand
Novel and Simple Synthesis of Brominated 1,10-Phenanthrolines
- D. Výprachtický, D. Kaňková, Veronika Pokorná, I. Kmínek, V. Dzhabarov, V. Cimrová
- 7 July 2014
A novel, simple, and reasonably efficient synthesis of 3,8-dibromo-1,10-phenanthroline, 3,6-dibromo-1,10-phenanthroline, 3,5,8-tribromo-1,10-phenanthroline, and 3,5,6,8-tetrabromo-1,10-phenanthroline… Expand
[Comparison of the effects of niflumic acid and aloxiprin in patients with progressive chronic rheumatoid arthritis in a double blind trial].
- O. Vojtíšek, D. Kaňková, K. Pavelka, D. Hándlová
- Chemistry, Medicine
- 1 August 1975
With the exception of the articular index disclosing a superior effect of niflumic acid, the other criteria showed no statistically significant differences between the effects of the two drugs. Expand
Self-assembled polymeric chelate nanoparticles as potential theranostic agents.
- M. Škodová, P. Černoch, +5 authors M. Hrubý
- Materials Science, Medicine
- Chemphyschem : a European journal of chemical…
- 21 December 2012
This study presents one of the new possible approaches in the diagnostics and therapy of cancer by using polymeric chelates as carriers using graft copolymers with a backbone containing 8-hydroxyquinoline-5-sulfonic acid chelating groups and poly(ethylene oxide) hydrophilic grafts. Expand