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Mechanistic studies of the triggered release of liposomal contents by matrix metalloproteinase-9.
Matrix metalloproteinases (MMPs) constitute a class of extracellular-matrix-degrading enzymes overexpressed in many cancers and contribute to the metastatic ability of the cancer cells. We haveExpand
Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity.
The atomic-resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors are reported. Each inhibitor contains a benzenesulfonamide prong and a cupricExpand
Enzyme-enzyme interactions and the regulation of metabolic reaction pathways.
Publisher Summary This chapter focuses on enzyme-enzyme interactions and the regulation of metabolic reaction pathways. The existence of functional enzyme-enzyme interactions is most obvious in theExpand
Biophysical chemistry of metabolic reaction sequences in concentrated enzyme solution and in the cell.
OF CATALYZED REACTIONS 177 Concentration of Enzymes in Cells 177 Effect of Environment on Chemical Reaction Equilibria .... 178 Effects of Enzyme-Enzyme Interactions on the Equilibrium DistributionExpand
Formulation of photocleavable liposomes and the mechanism of their content release.
In pursuit of designing photocleavable liposomes as drug delivery vehicles, we synthesized several amphiphilic lipids by connecting stearyl amine (as the non-polar tail) and charged amino acids (asExpand
A disintegrin and metalloproteinase-12 (ADAM12): function, roles in disease progression, and clinical implications.
BACKGROUND A disintegrin and metalloproteinase-12 (ADAM12) is a member of the greater ADAM family of enzymes: these are multifunctional, generally membrane-bound, zinc proteases for which there areExpand
"Uncorking" of liposomes by matrix metalloproteinase-9.
A triggered release methodology of liposomal contents via the enzyme MMP-9 is described.
Histone deacetylase activators: N-acetylthioureas serve as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate.
We report, for the first time, that certain N-acetylthiourea derivatives serve as highly potent and isozyme selective activators for the recombinant form of human histone deacetylase-8 in the assayExpand
Metabolite transfer via enzyme-enzyme complexes.
The concentrations of enzyme sites in cells are usually higher than the concentrations of cognate intermediary metabolites. Therefore metabolic pathways or substantial segments of pathways mayExpand
Molecular basis for the transfer of nicotinamide adenine dinucleotide among dehydrogenases.
NADH is transferred directly from one dehydrogenase enzyme site to another without intervention of the aqueous solvent whenever the two dehydrogenases are of opposite chiral specificity as regardsExpand
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