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Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity.
The atomic-resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors are reported, providing the first evidence verifying the structural basis of nanomolar affinity measured for two- prong inhibitors targeting the carbonicAnhydrase.
Mechanistic studies of the triggered release of liposomal contents by matrix metalloproteinase-9.
- A. Elegbede, Jayati Banerjee, S. Mallik
- Chemistry, BiologyJournal of the American Chemical Society
- 13 August 2008
The results of mechanistic studies of the MMP-9-triggered release of liposomal contents are reported, indicating that the observed differences in the release reflect the ability of theliposomal membrane to anneal the defects following the enzymatic cleavage of the liposome-incorporated lipopeptides.
Enzyme-enzyme interactions and the regulation of metabolic reaction pathways.
Metabolite transfer via enzyme-enzyme complexes.
Evidence is summarized suggesting that metabolite is transformed and transferred with equal facility everywhere in the direct transfer pathway.
Biophysical chemistry of metabolic reaction sequences in concentrated enzyme solution and in the cell.
Effects of Environment on Chemical Reaction Equilibria and Enzyme-Enzyme Interactions on the Equilibrium Distribution of Metabolites are studied.
A disintegrin and metalloproteinase-12 (ADAM12): function, roles in disease progression, and clinical implications.
Binding constants and stoichiometries of glyceraldehyde 3-phosphate dehydrogenase-tubulin complexes.
- V. Muronetz, Z. X. Wang, T. Keith, H. Knull, D. K. Srivastava
- Biology, ChemistryArchives of biochemistry and biophysics
- 1 September 1994
The catalytic activity of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) decreased (almost linearly) as a function of increasing concentrations of tubulin; the total loss in activity was attained…
Formulation of photocleavable liposomes and the mechanism of their content release.
- Binita Chandra, Rajesh Subramaniam, S. Mallik, D. K. Srivastava
- Chemistry, BiologyOrganic & biomolecular chemistry
- 20 April 2006
The overall mechanistic features intrinsic to the photocleavage of Asp, Glu and Lys containing o-nitrobenzyl conjugated lipids, and their potential applications in formulating liposomes (whose contents can be "unloaded" by the UV light) as drug delivery vehicles are discussed.
"Uncorking" of liposomes by matrix metalloproteinase-9.
A triggered release methodology of liposomal contents via the enzyme MMP-9 is described and its application in personalized medicine and drug discovery is described.