• Publications
  • Influence
Molecular and evolutionary basis of the cellular stress response.
  • D. Kültz
  • Biology, Medicine
  • Annual review of physiology
  • 2005
TLDR
Functional analysis of the minimal stress proteome yields information about key aspects of the cellular stress response, including physiological mechanisms of sensing membrane lipid, protein, and DNA damage; redox sensing and regulation; cell cycle control; macromolecular stabilization/repair; and control of energy metabolism. Expand
The Ecoresponsive Genome of Daphnia pulex
TLDR
The Daphnia genome reveals a multitude of genes and shows adaptation through gene family expansions, and the coexpansion of gene families interacting within metabolic pathways suggests that the maintenance of duplicated genes is not random. Expand
Phylogenetic and Functional Classification of Mitogen- and Stress-Activated Protein Kinases
  • D. Kültz
  • Biology, Medicine
  • Journal of Molecular Evolution
  • 1 May 1998
TLDR
It is demonstrated that amino acids conserved in allMAPKs are located primarily in the center of the protein around the catalytic cleft, and it is concluded that these residues are important for maintaining proper folding into the gross structure common to all MAPKs. Expand
Evolution of the cellular stress proteome: from monophyletic origin to ubiquitous function
  • D. Kültz
  • Biology, Medicine
  • Journal of Experimental Biology
  • 15 September 2003
TLDR
The need for a holistic view emphasizing the key aspects of the stress response is addressed by the following hypothesis: a phylogenetically conserved set of genes and pathways that mediate global macromolecular stabilization and repair to promote cellular and organismal integrity under suboptimal conditions. Expand
Regulation of gene expression by hypertonicity.
TLDR
This review considers how solutes help relieve the stress of hypertonicity and the nature of transporters and enzymes responsible for their variable accumulation and the molecular basis for osmotic regulation of these genes. Expand
In Vitro Biologic Activities of the Antimicrobials Triclocarban, Its Analogs, and Triclosan in Bioassay Screens: Receptor-Based Bioassay Screens
TLDR
Carbanilides, including TCC, enhanced hormone-dependent induction of ER- and AR-dependent gene expression but had little agonist activity, suggesting a new mechanism of action of endocrine-disrupting compounds. Expand
Rapid hyperosmotic coinduction of two tilapia (Oreochromis mossambicus) transcription factors in gill cells.
  • D. Fiol, D. Kültz
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 18 January 2005
TLDR
It is concluded that OSTF1 and TFIIB are critical elements of osmosensory signal transduction in euryhaline teleosts that mediate osmotic adaptation by means of transcriptional regulation. Expand
Mechanisms of seawater acclimation in a primitive, anadromous fish, the green sturgeon
TLDR
Green sturgeon osmo- and ionoregulate with similar mechanisms to more-derived teleosts, indicating the importance of these mechanisms during the evolution of fishes, although salinity acclimation may be more dependent on body size. Expand
Evolution of osmotic stress signaling via MAP kinase cascades.
  • D. Kültz, M. Burg
  • Biology, Medicine
  • The Journal of experimental biology
  • 1 November 1998
TLDR
This review highlights mitogen-activated protein kinase (MAPK) cascades as important intracellular signal-transduction pathways activated in response to changes in osmolality and suggests regulation of the cell cycle as part of the cellular stress response. Expand
A novel tilapia prolactin receptor is functionally distinct from its paralog
TLDR
The data reveal that tilapia has two PRLR genes whose protein products respond uniquely to PRL and activate different downstream pathways. Expand
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