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Identification of Pathogenic Mechanisms of COCH Mutations, Abolished Cochlin Secretion, and Intracellular Aggregate Formation: Genotype–Phenotype Correlations in DFNA9 Deafness and Vestibular Disorder
Mutations in COCH (coagulation factor C homology) cause autosomal‐dominant nonsyndromic hearing loss with variable degrees of clinical onset and vestibular malfunction. We selected eightExpand
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Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane.
It is well known that UVB (290-320 nm) induces inflammation in skin by the transcription and release of cytokines and chemokines from skin keratinocytes. In addition, it is considered thatExpand
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Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening
Lung cancer shows substantial genetic and phenotypic heterogeneity across individuals, driving a need for personalised medicine. Here, we report lung cancer organoids and normal bronchial organoidsExpand
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A one-stop microfluidic-based lung cancer organoid culture platform for testing drug sensitivity.
Microfluidic devices as translational research tools provide a potential alternative to animal experiments due to their ability to mimic physiological parameters. Several approaches that can be usedExpand
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The Association between Metabolic Syndrome or Chronic Kidney Disease and Hearing Thresholds in Koreans: The Korean National Health and Nutrition Examination Survey 2009-2012
Background The aim of this study was to determine whether metabolic syndrome (MetS) or chronic kidney disease (CKD) is associated with hearing thresholds in the general Korean population. PatientsExpand
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Urinary tract injuries during pelvic surgery: incidence rates and predisposing factors
ObjectiveTo review the cases of urinary tract injury following major pelvic surgery that were treated in our hospital over the last 12 years, in relation to possible predisposing factors andExpand
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Intussuscepted Sigmoid Colonic Lipoma Mimicking Carcinoma
Colonic lipomas are the most common nonepithelial tumor, and they are the third most common tumor, after hyperplastic and adenomatous polyps (1). The majority of colonic lipomas are small andExpand
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A missense variant of the ATP1A2 gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine
Hereditary sensorineural hearing loss is an extremely clinical and genetic heterogeneous disorder in humans. Especially, syndromic hearing loss is subdivided by combinations of various phenotypes,Expand
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Molecular and Clinical Characterization of the Variable Phenotype in Korean Families with Hearing Loss Associated with the Mitochondrial A1555G Mutation
Hearing loss, which is genetically heterogeneous, can be caused by mutations in the mitochondrial DNA (mtDNA). The A1555G mutation of the 12S ribosomal RNA (rRNA) gene in the mtDNA has beenExpand
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Leiomyomas of the female urethra and bladder: a report of five cases and review of the literature
Through the experience of five cases of leiomyoma developed in the female bladder and urethra with a review of the literature, we have made an effort to characterize the association of symptom withExpand
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