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Nitric oxide. I. Physiological chemistry of nitric oxide and its metabolites:implications in inflammation.
TLDR
Consideration of the physiological chemistry of NO and its metabolites will hopefully allow one to identify which of the many NO-dependent reactions are important in modulating the inflammatory response and may help in the design of new therapeutic strategies for the treatment of inflammatory tissue injury.
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Concomitant S‐, N‐, and heme‐nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo
TLDR
The findings suggest that NO generation in vivo leads to concomitant formation of RSNOs, nitrosamines, and nitrosylhemes with considerable variation between rodents and primates, highlighting the difficulty in comparing data between different animal models and extrapolating results from experimental animals to human physiology.
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Oxidation and Nitrosation of Thiols at Low Micromolar Exposure to Nitric Oxide
TLDR
The data indicate that RSNO formation is favored at oxygen concentrations that typically occur in tissues, and that nitrosothiol formation in vivo depends not only on the availability of ⋅NO and O2 but also on the degree of oxidative stress by affecting the steady-state concentration of thiyl radicals.
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Reaction of Superoxide and Nitric Oxide with Peroxynitrite
TLDR
It is concluded that the oxidative processes initiated by the free radical intermediates formed from the decomposition of peroxynitrite are inhibited by excess production of ⋅NO or O⨪2, whereas oxidative pathways involving a direct reaction with each other are not altered.
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Increased nitric oxide-dependent nitrosylation of 4,5-diaminofluorescein by oxidants: implications for the measurement of intracellular nitric oxide.
  • D. Jourd’heuil
  • Chemistry, Biology
    Free radical biology & medicine
  • 1 September 2002
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Cytoglobin Is Expressed in the Vasculature and Regulates Cell Respiration and Proliferation via Nitric Oxide Dioxygenation*
TLDR
Results indicate that cytoglobin contributes to cell-mediated NO dioxygenation and represents an important NO sink in the vascular wall.
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The cytotoxicity of nitroxyl: possible implications for the pathophysiological role of NO.
TLDR
The data in this study suggest that nitroxyl may contribute to the cytotoxicity associated with an enhanced expression of the L-arginine:NO pathway under different biological conditions.
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Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration.
TLDR
STIM1 and Orai1 are important components for PDGF-mediated Ca(2+) entry and migration in VSMC and are upregulated in vivo during vascular injury and provide insights linking PDGF to STIM1/Orai 1 during neointima formation.
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Performance of diamino fluorophores for the localization of sources and targets of nitric oxide.
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I. Physiological chemistry of nitric oxide and its metabolites: implications in inflammation.
TLDR
Consideration of the physiological chemistry of NO and its metabolites will hopefully allow one to identify which of the many NO-dependent reactions are important in modulating the inflammatory response and may help in the design of new therapeutic strategies for the treatment of inflammatory tissue injury.
View on PubMed
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