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Effect of fluconazole on the pharmacokinetics of eprosartan and losartan in healthy male volunteers
- D. Kazierad, D. Martin, +5 authors D. Jorkasky
- Clinical pharmacology and therapeutics
- 1 October 1997
To investigate the effect of steady‐state fluconazole administration on the disposition of eprosartan, losartan, and E‐3174.
Interpreting the International Normalized Ratio (INR) in individuals receiving argatroban and warfarin.
- S. Sheth, R. DiCicco, M. J. Hursting, T. Montague, D. Jorkasky
- Thrombosis and haemostasis
- 1 March 2001
The effects of argatroban, a direct thrombin inhibitor, on the International Normalized Ratio (INR), activated partial thromboplastin time (aPTT) and functional factor X during warfarin… Expand
Man Versus Machine: Is There an Optimal Method for QT Measurements in Thorough QT Studies?
Electrocardiographic (ECG) recordings from 3 placebo‐controlled thorough QT healthy volunteer studies were used to compare QT intervals obtained by manual measurement with those generated by ECG… Expand
Pharmacokinetics of intravenously and orally administered eprosartan in healthy males: absolute bioavailability and effect of food
- D. Tenero, D. Martin, +6 authors D. Jorkasky
- Medicine, Chemistry
- Biopharmaceutics & drug disposition
- 1 September 1998
Eighteen healthy males received a single 300 mg oral dose of eprosartan as the commercial wet granulation formulation under fasting conditions and following a high‐fat breakfast and a single 20 mg… Expand
Long-term renal function in kidney donors: a comparison of donors and their siblings.
To assess the effects of unilateral nephrectomy, we evaluated renal function and hypertension in kidney donors who had had nephrectomies 10 years ago or more and siblings who had not had… Expand
Effect of a new synthetic hexapeptide to selectively stimulate growth hormone release in healthy human subjects.
- B. Ilson, D. Jorkasky, R. T. Curnow, R. M. Stote
- The Journal of clinical endocrinology and…
- 1 July 1989
Growth hormone-releasing peptide (GHRP, SK&F 110679) is a hexapeptide (His-DTrp-Ala-Trp-DPhe-LysNH2) that selectively stimulates the release of growth hormone (GH) but not other pituitary hormones in… Expand
Prophylaxis of serious cytomegalovirus infection in renal transplant candidates using live human cytomegalovirus vaccine. Interim results of a randomized controlled trial.
We report the interim results of a randomized, double-blind, placebo-controlled, clinical trial of prophylactic, live, attenuated cytomegalovirus (CMV) vaccination (Towne strain of CMV) of renal… Expand
Cardiovascular effects of i.v. granisetron at two administration rates and of ondansetron in healthy adults.
- S. Boike, B. Ilson, N. Zariffa, D. Jorkasky
- American journal of health-system pharmacy : AJHP…
- 15 May 1997
The cardiovascular effects of granisetron given as a 30-second i.v. bolus dose and of granisetron and ondansetron given by currently recommended methods were studied. Healthy adults 18 to 50 years of… Expand
Safety and Pharmacokinetics of an Intramuscular Monoclonal Antibody (SB 209763) against Respiratory Syncytial Virus (RSV) in Infants and Young Children at Risk for Severe RSV Disease
- H. Meissner, J. Groothuis, +11 authors K. A. Thompson
- Antimicrobial Agents and Chemotherapy
- 1 May 1999
ABSTRACT We conducted a multicenter, double-blind, placebo-controlled, randomized trial of a humanized monoclonal antibody against a respiratory syncytial virus (RSV) fusion protein (SB 209763) to… Expand
Renal allografts: prospective analysis of Doppler sonography.
Fifty-six consecutively transplanted renal allografts were prospectively evaluated with serial Doppler sonographic examinations. Thirty-eight episodes of transplant rejection in 32 patients (63%… Expand