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Effect of fluconazole on the pharmacokinetics of eprosartan and losartan in healthy male volunteers
To investigate the effect of steady‐state fluconazole administration on the disposition of eprosartan, losartan, and E‐3174.
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Interpreting the International Normalized Ratio (INR) in individuals receiving argatroban and warfarin.
The effects of argatroban, a direct thrombin inhibitor, on the International Normalized Ratio (INR), activated partial thromboplastin time (aPTT) and functional factor X during warfarinExpand
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Man Versus Machine: Is There an Optimal Method for QT Measurements in Thorough QT Studies?
Electrocardiographic (ECG) recordings from 3 placebo‐controlled thorough QT healthy volunteer studies were used to compare QT intervals obtained by manual measurement with those generated by ECGExpand
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Pharmacokinetics of intravenously and orally administered eprosartan in healthy males: absolute bioavailability and effect of food
Eighteen healthy males received a single 300 mg oral dose of eprosartan as the commercial wet granulation formulation under fasting conditions and following a high‐fat breakfast and a single 20 mgExpand
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Long-term renal function in kidney donors: a comparison of donors and their siblings.
To assess the effects of unilateral nephrectomy, we evaluated renal function and hypertension in kidney donors who had had nephrectomies 10 years ago or more and siblings who had not hadExpand
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Effect of a new synthetic hexapeptide to selectively stimulate growth hormone release in healthy human subjects.
Growth hormone-releasing peptide (GHRP, SK&F 110679) is a hexapeptide (His-DTrp-Ala-Trp-DPhe-LysNH2) that selectively stimulates the release of growth hormone (GH) but not other pituitary hormones inExpand
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Prophylaxis of serious cytomegalovirus infection in renal transplant candidates using live human cytomegalovirus vaccine. Interim results of a randomized controlled trial.
We report the interim results of a randomized, double-blind, placebo-controlled, clinical trial of prophylactic, live, attenuated cytomegalovirus (CMV) vaccination (Towne strain of CMV) of renalExpand
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Cardiovascular effects of i.v. granisetron at two administration rates and of ondansetron in healthy adults.
The cardiovascular effects of granisetron given as a 30-second i.v. bolus dose and of granisetron and ondansetron given by currently recommended methods were studied. Healthy adults 18 to 50 years ofExpand
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Safety and Pharmacokinetics of an Intramuscular Monoclonal Antibody (SB 209763) against Respiratory Syncytial Virus (RSV) in Infants and Young Children at Risk for Severe RSV Disease
ABSTRACT We conducted a multicenter, double-blind, placebo-controlled, randomized trial of a humanized monoclonal antibody against a respiratory syncytial virus (RSV) fusion protein (SB 209763) toExpand
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Renal allografts: prospective analysis of Doppler sonography.
Fifty-six consecutively transplanted renal allografts were prospectively evaluated with serial Doppler sonographic examinations. Thirty-eight episodes of transplant rejection in 32 patients (63%Expand
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