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p38(MAPK): stress responses from molecular mechanisms to therapeutics.
The p38(MAPK) protein kinases affect a variety of intracellular responses, with well-recognized roles in inflammation, cell-cycle regulation, cell death, development, differentiation, senescence andExpand
The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer
Endocrine therapy has successfully been used to treat estrogen receptor (ER)-positive breast cancer, but this invariably fails with cancers becoming refractory to treatment. Emerging evidence hasExpand
KDM4B is a Master Regulator of the Estrogen Receptor Signalling Cascade
The importance of the estrogen receptor (ER) in breast cancer (BCa) development makes it a prominent target for therapy. Current treatments, however, have limited effectiveness, and hence theExpand
The role of humic non-exchangeable binding in the promotion of metal ion transport in groundwaters in the environment.
Metal ions form strong complexes with humic substances. When the metal ion is first complexed by humic material, it is bound in an 'exchangeable' mode. The metal ion in this fraction is stronglyExpand
FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer
Retention of androgen receptor (AR) signalling in castrate-resistant prostate cancer (CRPC) highlights the requirement for the development of more effective AR targeting therapies. A key mechanism ofExpand
Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy
The persistence of androgen receptor (AR) signalling in castrate-resistant prostate cancer (CRPC) highlights the unmet clinical need for the development of more effective AR targeting therapies. AExpand
The Histone Demethylase Enzymes KDM3A and KDM4B Co-Operatively Regulate Chromatin Transactions of the Estrogen Receptor in Breast Cancer
Many estrogen receptor (ER)-positive breast cancers develop resistance to endocrine therapy but retain canonical receptor signalling in the presence of selective ER antagonists. NumerousExpand
Differential regulation of the androgen receptor by protein phosphatase regulatory subunits
The Androgen Receptor (AR) is a key molecule in the development, maintenance and progression of prostate cancer (PC). However, the relationship between the AR and co-regulatory proteins thatExpand
Factors affecting the dissociation of metal ions from humic substances
Abstract Previously, it has been suggested that metal ions complexed to humic acid in the environment might show slower dissociation than those added to humic substances in the laboratory, which hasExpand
IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway
Abstract Resistance to androgen receptor (AR) targeting therapeutics in prostate cancer (PC) is a significant clinical problem. Mechanisms by which this is accomplished include AR amplification andExpand