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Early and Longitudinal Evaluations of Treated Infants and Children and Untreated Historical Patients with Congenital Toxoplasmosis: The Chicago Collaborative Treatment Trial
TLDR
Most remarkable were the normal developmental, neurological, and ophthalmologic findings at the early follow-up evaluations of many--but not all--of the treated children despite severe manifestations, such as substantial systemic disease, hydrocephalus, microcephalus and multiple intracranial calcifications, and extensive macular destruction detected at birth. Expand
Endocrine pancreas in cystic fibrosis: an immunohistochemical study.
The pancreases of 17 patients who had cystic fibrosis with and without diabetes mellitus were evaluated at autopsy by routine staining and immunohistochemical methods for insulin, glucagon,Expand
Antiproliferative Mechanisms of a Transcription Factor Decoy Targeting Signal Transducer and Activator of Transcription (STAT) 3: The Role of STAT1
TLDR
The results suggest that the therapeutic mechanisms of STAT3 blockade using a transcription factor decoy are independent of STAT1 activation, a potential tumor suppressor. Expand
Crosstalking between Androgen and PI3K/AKT Signaling Pathways in Prostate Cancer Cells*
TLDR
It was shown that the androgen depletion or knockdown of AR expression results in elevated levels of active phosphorylated AKT in prostate cancer cells, and that Pten loss directly represses endogenous Ar expression in prostatic epithelial cells. Expand
Curcumin inhibits NFkappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells.
TLDR
The results suggest that curcumin is a potent radiosensitizer and may act by overcoming the effects of radiation-induced NFkappaB mediated pro-survival gene expression in neuroblastoma. Expand
Modified milk powder supplemented with immunostimulating whey protein concentrate (IMUCARE) enhances immune function in mice
TLDR
Investigation of the effects of a known immunostimulatory WPC when delivered to mice in a modified milk powder, nutritionally balanced for young children, confirms that IMUCARE WPC retains immunoenhancing efficacy when delivered in a nutrantically balanced milk product and additionally identifies nutristically balanced MMP as a potential immunostIMulatory dietary food product. Expand
Comparison of tumor and normal tissue dose for accelerated partial breast irradiation using an electronic brachytherapy eBx source and an Iridium‐192 source
TLDR
This dosimetric comparison of eBx and Iridium sources demonstrates that both forms of balloon‐based brachytherapy provide comparable dose to the planning target volume, resulting in significantly increased tissue sparing in the heart and ipsilateral lung. Expand
A simple model for predicting the signal for a head‐mounted transmission chamber system, allowing IMRT in‐vivo dosimetry without pretreatment linac time
TLDR
This work presents the development of a predictive algorithm for the expected signal, eradicating the need to spend time on the linac prior to treatment, and thereby making the process more efficient. Expand
Thyrocalcitonin-containing cells in the Di George anomaly.
TLDR
It is concluded that thyroid C cell deficiency is present in most patients with Di George anomaly, suggesting a relationship between these cells and development of derivatives of the third through fifth visceral pouches. Expand
Etomidate Use and Postoperative Outcomes among Cardiac Surgery Patients
TLDR
There was no evidence to suggest that etomidate exposure was associated with severe hypotension, longer mechanical ventilation hours, longer length of hospital stay, or in-hospital mortality, and Etomidate should remain an option for induction of anesthesia in cardiac surgery patients. Expand
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