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In vivo proton magnetic resonance spectroscopy of the normal aging human brain.
TLDR
The findings demonstrate that biochemical alterations are associated with aging in the frontal gray matter and there might be an increase in the brain density as indicated by increased metabolite concentrations and decreased brain water content with aging. Expand
Cysteine string proteins: a potential link between synaptic vesicles and presynaptic Ca2+ channels.
TLDR
Docked synaptic vesicles may regulate presynaptic calcium channels and neurotransmitter release and cysteine string proteins are essential subunits or modulators of these channels. Expand
In vivo 1H MRS choline: correlation with in vitro chemistry/histology.
We correlated the in vivo 1H Magnetic Resonance Spectroscopy (MRS) concentration of the choline peak (CHO) with in vitro chemical measures of choline-containing compounds and a histological grade ofExpand
The pharmacology of ryanodine.
TLDR
It seems reasonable to conclude that ryanodine interferes with intracellular Ca ++ translocation mechanisms that normally lower the sarcoplasmic concentration and thereby effect relaxation, and this proposal provides a reasonable explanation for many of the effects observed after ryanadine treatment. Expand
A CHOLINERGIC MECHANISM IN THE BRAINSTEM RETICULAR FORMATION: INDUCTION OF PARADOXICAL SLEEP.
TLDR
It is concluded that the receptor sites involved are muscarinic, and that the effects described most probably occur as a result of the selective activation of inhibitory neurones. Expand
Choline deficiency: A cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation
TLDR
The hepatic steatosis associated with parenteral nutrition can be ameliorated, and possibly prevented, with choline supplementation, and choline may be an essential nutrient for patients who require long‐term parenTERal nutrition. Expand
Behavioral, neurochemical and physiological effects of repeated exposures to subsymptomatic levels of the anticholinesterase, soman.
TLDR
The results of the present series of experiments show quite clearly that exposure to the antiChE, soman, at subsymptomatic levels can produce differential effects on enzymatic, physiological and behavioral functions, i.e., some of these functions may be affected while others are not. Expand
The Effect of Lecithin Supplementation on Plasma Choline Concentrations During a Marathon
TLDR
Short-term lecithin supplementation prior to a marathon maintains normal plasma free choline concentration during the race, but failed to improve performance. Expand
Choline deficiency causes reversible hepatic abnormalities in patients receiving parenteral nutrition: proof of a human choline requirement: a placebo-controlled trial.
TLDR
The data suggest choline is a required nutrient for long-term home TPN patients and suggests choline deficiency is a significant contributor to the development of TPN-associated liver disease. Expand
Stereochemical differences in the metabolism of 3,4-methylenedioxymethamphetamine in vivo and in vitro: a pharmacokinetic analysis.
TLDR
The high levels of MDA observed after administration of (+)MDMA to intact animals suggest that this active metabolite could be important in the overall effects of (+), and the difficulties in extrapolation of in vitro observations to in vivo disposition are suggested. Expand
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