• Publications
  • Influence
Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
Five centrally acting sympathomimetic amines, d‐amphetamine, d‐methamphetamine, ephedrine, phenmetrazine, and methylphenidate, were studied in man. All of these agents increased blood pressure andExpand
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Human pharmacology and abuse potential of the analgesic buprenorphine: a potential agent for treating narcotic addiction.
Buprenorphine was evaluated for its abuse potential and utility in treating narcotic addiction. The drug was morphine-like but was 25 to 50 times more potent than morphine and was longer-acting.Expand
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Abuse liability and safety of oral lisdexamfetamine dimesylate in individuals with a history of stimulant abuse
Abstract Lisdexamfetamine dimesylate (LDX) is the first prodrug stimulant and is indicated for the treatment of attention-deficit/hyperactivity disorder. A single-centre, double-blind, randomised,Expand
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Human pharmacology of intravenous lisdexamfetamine dimesylate: abuse liability in adult stimulant abusers
Abstract The objective of this study is to determine the safety, tolerability and abuse liability of single intravenous (i.v.) doses of lisdexamfetamine dimesylate (LDX) and immediate-releaseExpand
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A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts
The efficacy of buprenorphine and methadone was compared in the outpatient detoxification of heroin addicts. Forty‐five patients were randomized to receive either sublingual buprenorphine or oralExpand
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An evaluation of the abuse potential of modafinil using methylphenidate as a reference
  • D. Jasinski
  • Psychology, Medicine
  • Journal of psychopharmacology
  • 1 January 2000
Modafinil is a unique wake-promoting agent. Preclinical studies indicate a mechanism of action which is distinct from that of amphetamine or methylphenidate. To compare the pharmacodynamic profilesExpand
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Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome.
This study was designed to compare the neonatal abstinence syndrome (NAS) in neonates of methadone and buprenorphine maintained pregnant opioid-dependent women and to provide preliminary safety andExpand
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Abuse potential and pharmacological comparison of tramadol and morphine.
The purpose of the study was to assess the abuse potential of the opioid analgesic tramadol. Tramadol (75, 150 and 300 mg), morphine (15 and 30 mg) and placebo were tested intramuscularly inExpand
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Assessment of the Abuse Potentiality of Morphinelike Drugs (Methods Used in Man)
As therapeutic agents, morphine and morphinelike drugs are indispensable, but these same agents are liable to nontherapeutic self-ingestion by segments of the population. Society has condemned thisExpand
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Challenges in the Development of Prescription Opioid Abuse-deterrent Formulations
Opioid analgesics remain the cornerstone of effective management for moderate-to-severe pain. In the face of persistent lack of access to opioids by patients with legitimate pain problems, the rateExpand
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