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Human pharmacology and abuse potential of the analgesic buprenorphine: a potential agent for treating narcotic addiction.
Buprenorphine has potential for treating narcotic addiction since it is acceptable to addicts, is long-acting, produces a low level of physical dependence such that patients may be easily detoxified, is less toxic than drugs used for maintenance therapy, and blocks the effects of narcotics.
Abuse liability and safety of oral lisdexamfetamine dimesylate in individuals with a history of stimulant abuse
At an equivalent amount of amphetamine base taken orally, LDX 100 mg had attenuated responses on measures of abuse liability compared with immediate-release d-amphetamine 40 mg, and diethylpropion hydrochloride, a Schedule IV amphetamine-like stimulant, on abuse-related liking scores.
A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts
The results of this clinical trial indicated that buprenorphine was acceptable to patients and as effective as methadone in the detoxification treatment of heroin addicts.
An evaluation of the abuse potential of modafinil using methylphenidate as a reference
  • D. Jasinski
  • Psychology, Medicine
    Journal of psychopharmacology
  • 1 January 2000
The profile of physiological effects for modafinil differed from methylphenidate in that it showed greater inhibition of observed and reported sleep, less facilitation of orthostatic tachycardia and less reduction of caloric intake, consistent with preclinical pharmacological data suggesting that modaf inil is not an amphetamine-like agent.
Human pharmacology of intravenous lisdexamfetamine dimesylate: abuse liability in adult stimulant abusers
LDX administered intravenously did not produce significant subjective abuse-related liking scores at assessed doses, and was well tolerated in this population of adult substance abusers.
Challenges in the Development of Prescription Opioid Abuse-deterrent Formulations
This manuscript captures the main consensus opinions of experts on opioid abuse and diversion, and information gleaned from a review of the relevant published literature, to identify major impediments to the development of opioid abuse-deterrent formulations and offer strategies that may accelerate their commercialization.
Assessment of the Abuse Potentiality of Morphinelike Drugs (Methods Used in Man)
In an attempt to develop analgesics, antitussives, and antidiarrheals that were devoid of those properties of morphine leading to abuse, a large number of drugs have been synthesized and studied.