Phosphodiesterase Inhibition Rescues Chronic Cognitive Deficits Induced by Traumatic Brain Injury
- D. J. Titus, A. Sakurai, C. Atkins
- Biology, PsychologyJournal of Neuroscience
- 20 March 2013
The results indicate that the PDE4 inhibitor rolipram rescues cognitive impairments after TBI, and this may be mediated through increased CREB activation during learning.
Age-dependent alterations in cAMP signaling contribute to synaptic plasticity deficits following traumatic brain injury
- D. J. Titus, C. Furones, Y. Kang, C. Atkins
- Biology, PsychologyNeuroscience
- 12 February 2013
Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodiesterase 4B Inhibitor
- D. J. Titus, N. Wilson, C. Atkins
- Biology, PsychologyJournal of Neuroscience
- 6 July 2016
A selective phosphodiesterase 4B (PDE4B) inhibitor reduces chronic cognitive deficits after TBI and rescues deficits in hippocampal long-term potentiation, suggesting that PDE4B inhibition has the potential to improve learning and memory ability and overall functioning for people living with TBI.
Properties of a Distinct Subpopulation of GABAergic Commissural Interneurons That Are Part of the Locomotor Circuitry in the Neonatal Spinal Cord
- Linying Wu, P. Sonner, D. J. Titus, Erik P. Wiesner, F. J. Alvarez, L. Ziskind-Conhaim
- BiologyJournal of Neuroscience
- 30 March 2011
It is proposed that this population of GABAergic INs in the spinal cord of GAD67::GFP transgenic mice forms a class of local commissural inhibitory interneurons that are integral component of the locomotor circuitry.
Emergence of cognitive deficits after mild traumatic brain injury due to hyperthermia
- D. J. Titus, C. Furones, C. Atkins, W. Dietrich
- Biology, PsychologyExperimental Neurology
- 31 January 2015
Traumatic Brain Injury Upregulates Phosphodiesterase Expression in the Hippocampus
- N. Wilson, D. J. Titus, A. Oliva, C. Furones, C. Atkins
- BiologyFrontiers in Systems Neuroscience
- 5 February 2016
Several possible PDE targets are identified for reducing hippocampal synaptic plasticity deficits and improving cognitive function acutely after TBI, including rolipram, a pan-PDE4 inhibitor.
Sensory modulation of locomotor-like membrane oscillations in Hb9-expressing interneurons.
- C. Hinckley, Eric P. Wiesner, G. Mentis, D. J. Titus, L. Ziskind-Conhaim
- Biology, PsychologyJournal of Neurophysiology
- 1 June 2010
The findings that low-threshold, presumably muscle afferents, synapse directly onto these interneurons and perturb their induced locomotor-like membrane oscillations in a pattern that remains phase-locked with motor bursts support the hypothesis that Hb9 INs are part of the sensorimotor circuitry that regulates the pattern of locomotor rhythms in the isolated cord.
Early Life Stress Exacerbates Outcome after Traumatic Brain Injury.
- Chantal Marie Sanchez, D. J. Titus, N. Wilson, J. E. Freund, C. Atkins
- Psychology, BiologyJournal of Neurotrauma
- 29 August 2020
The findings indicate that ELS is a risk factor for worsened outcome after TBI and results in persistent learning and memory deficits, worsened cortical pathology, and an exacerbation of the hormonal stress response.
Phosphodiesterase inhibitors as therapeutics for traumatic brain injury.
- D. J. Titus, A. Oliva, N. Wilson, C. Atkins
- BiologyCurrent pharmaceutical design
- 31 December 2014
How signaling through cyclic nucleotides contributes to the pathology of traumatic brain injury in the acute and chronic stages of recovery is discussed and phosphodiesterase inhibitors are discussed.
Synaptic integration of rhythmogenic neurons in the locomotor circuitry: the case of Hb9 interneurons
- L. Ziskind-Conhaim, G. Mentis, Eric P. Wiesner, D. J. Titus
- Biology, PsychologyAnnals of the New York Academy of Sciences
- 1 June 2010
The findings suggest that the rhythmogenic Hb9 INs are integral components of the sensorimotor circuitry that regulate locomotor‐like activity in the spinal cord.
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