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Crystalline solids.
Many drugs exist in the crystalline solid state due to reasons of stability and ease of handling during the various stages of drug development. Crystalline solids can exist in the form of polymorphs,Expand
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THEORY AND ORIGIN OF POLYMORPHISM
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Physical stability of amorphous pharmaceuticals: Importance of configurational thermodynamic quantities and molecular mobility.
This work relates the thermodynamic quantities (Gc, Hc, and Sc) and the molecular mobility values (1/tau) of five structurally diverse amorphous compounds to their crystallization behavior. The modelExpand
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Polymorph screening: influence of solvents on the rate of solvent-mediated polymorphic transformation.
Solvent-mediated polymorphic transformation is an efficient technique to obtain the most stable polymorph. The rate of solvent-mediated polymorphic transformation of sulfamerazine at 24 degrees C inExpand
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NON – LINEAR VAN'T HOFF SOLUBILITY TEMPERATURE PLOTS AND THEIR PHARMACEUTICAL INTERPRETATION
Abstract The aqueous solubilities of acetaminophen, adipic acid and the parabens (methyl, ethyl, propyl and butyl p -hydroxybenzoate) have been measured over a temperature span of at least 50°C. BothExpand
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Solubility behavior of organic compounds
Solubility, Intermolecular Forces, and Thermodynamics Activities of Solutes, Selection of Standard State and Henry's Law Constants Specific Interactions in Solubility Phenomena Influence ofExpand
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Polymorphism in Piroxicam
Piroxciam is a polymorphic drug. However, reports on the number and nomenclature of the polymorphs of piroxicam and the complete hydrogen-bonding patterns of piroxicam molecules in the crystal formsExpand
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Influence of Crystal Structure on the Tableting Properties of Sulfamerazine Polymorphs
AbstractPurpose. To understand the influence of polymorphic structure on the tableting properties of sulfamerazine. Methods. Bulk powders of sulfamerazine polymorph I and of two batches, II(A) andExpand
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Identifying the Stable Polymorph Early in the Drug Discovery–Development Process
The thermodynamically most stable polymorph under ambient conditions is almost without exception the most desirable crystalline form for development by a pharmaceutical company. It is, therefore,Expand
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