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- Publications
- Influence
Crystalline solids.
- S. Vippagunta, H. Brittain, D. J. Grant
- Medicine
- Advanced drug delivery reviews
- 2001
Many drugs exist in the crystalline solid state due to reasons of stability and ease of handling during the various stages of drug development. Crystalline solids can exist in the form of polymorphs,… Expand
Physical stability of amorphous pharmaceuticals: Importance of configurational thermodynamic quantities and molecular mobility.
- D. Zhou, G. Zhang, D. Law, D. J. Grant, E. Schmitt
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1 August 2002
This work relates the thermodynamic quantities (Gc, Hc, and Sc) and the molecular mobility values (1/tau) of five structurally diverse amorphous compounds to their crystallization behavior. The model… Expand
Polymorph screening: influence of solvents on the rate of solvent-mediated polymorphic transformation.
- C. H. Gu, V. Young, D. J. Grant
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1 November 2001
Solvent-mediated polymorphic transformation is an efficient technique to obtain the most stable polymorph. The rate of solvent-mediated polymorphic transformation of sulfamerazine at 24 degrees C in… Expand
NON – LINEAR VAN'T HOFF SOLUBILITY TEMPERATURE PLOTS AND THEIR PHARMACEUTICAL INTERPRETATION
- D. J. Grant, M. Mehdizadeh, A. Chow, J. E. Fairbrother
- Chemistry
- 1984
Abstract The aqueous solubilities of acetaminophen, adipic acid and the parabens (methyl, ethyl, propyl and butyl p -hydroxybenzoate) have been measured over a temperature span of at least 50°C. Both… Expand
Solubility behavior of organic compounds
- D. J. Grant, Takeru Higuchi
- Chemistry
- 1990
Solubility, Intermolecular Forces, and Thermodynamics Activities of Solutes, Selection of Standard State and Henry's Law Constants Specific Interactions in Solubility Phenomena Influence of… Expand
- 210
- 5
Polymorphism in Piroxicam
- A. Sheth, S. Bates, F. Muller, D. J. Grant
- Chemistry
- 1 September 2004
Piroxciam is a polymorphic drug. However, reports on the number and nomenclature of the polymorphs of piroxicam and the complete hydrogen-bonding patterns of piroxicam molecules in the crystal forms… Expand
Influence of Crystal Structure on the Tableting Properties of Sulfamerazine Polymorphs
- C. Sun, D. J. Grant
- Chemistry, Medicine
- Pharmaceutical Research
- 11 July 2001
AbstractPurpose. To understand the influence of polymorphic structure on the tableting properties of sulfamerazine.
Methods. Bulk powders of sulfamerazine polymorph I and of two batches, II(A) and… Expand
Solid-state pharmaceutical chemistry
- S. Byrn, R. Pfeiffer, G. Stephenson, D. J. Grant, W. Gleason
- Chemistry
- 1 August 1994
Identifying the Stable Polymorph Early in the Drug Discovery–Development Process
- J. Miller, Benjamin M. Collman, Landon R Greene, D. J. Grant, A. Blackburn
- Chemistry, Medicine
- Pharmaceutical development and technology
- 1 January 2005
The thermodynamically most stable polymorph under ambient conditions is almost without exception the most desirable crystalline form for development by a pharmaceutical company. It is, therefore,… Expand