D. J. Goetz

Publications91
h-index29
Citations2,523
Highly Influential Citations96
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Leukocyte-inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo
TLDR
The leukocyte–inspired particles have adhesion efficiencies similar to that of leukocytes and were shown to target each of the major inducible endothelial cell adhesion molecules that are up-regulated at sites of pathological inflammation.
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Isolated P-selectin Glycoprotein Ligand-1 Dynamic Adhesion to P- and E-selectin
TLDR
It is demonstrated that the first 19 amino acids of PSGL-1 are sufficient for attachment and rolling on both E- and P-selectin and suggested that a sialyl Lewis x–containing glycan at Threonine-16 is critical for this sequence of amino acids to mediate attachment to E-and P- selectin.
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Supercritical carbon dioxide pretreatment of corn stover and switchgrass for lignocellulosic ethanol production.
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Sialyl Lewis(x)/E-selectin-mediated rolling in a cell-free system.
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Phenyl Methimazole Inhibits TNF-α-Induced VCAM-1 Expression in an IFN Regulatory Factor-1-Dependent Manner and Reduces Monocytic Cell Adhesion to Endothelial Cells1
TLDR
Results indicate that phenyl methimazole can reduce TNF-α-induced VCAM-1 expression in an IFN regulatory factor-1-dependent manner and that this contributes significantly to reduced monocytic cell adhesion to T NF- α-activated HAEC.
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Dynamics of neutrophil rolling over stimulated endothelium in vitro.
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PSGL-1 derived from human neutrophils is a high-efficiency ligand for endothelium-expressed E-selectin under flow.
TLDR
The results support the hypotheses that 1) PSGL-1 is a high-efficiency tethering ligand for E-selectin, 2) ligand biochemistry can significantly influence initial tethering to E- selectin, and 3) PS GL-1 tethering can occur via non-HECA-452 reactive epitopes.
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Hyaluronan microspheres for sustained gene delivery and site-specific targeting.
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Particle diameter influences adhesion under flow.
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Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis.
TLDR
It is concluded that functional TLR3 are present on thyrocytes;TLR3 downstream signals can be overexpressed by pathogen-related stimuli; overexpression can be reversed by phenylmethimazole to a significantly greater extent than MMI.
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