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Leukocyte-inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo
- Harshad S. Sakhalkar, M. Dalal, D. J. Goetz
- Biology, MedicineProceedings of the National Academy of Sciences…
- 10 December 2003
The leukocyte–inspired particles have adhesion efficiencies similar to that of leukocytes and were shown to target each of the major inducible endothelial cell adhesion molecules that are up-regulated at sites of pathological inflammation.
Isolated P-selectin Glycoprotein Ligand-1 Dynamic Adhesion to P- and E-selectin
It is demonstrated that the first 19 amino acids of PSGL-1 are sufficient for attachment and rolling on both E- and P-selectin and suggested that a sialyl Lewis x–containing glycan at Threonine-16 is critical for this sequence of amino acids to mediate attachment to E-and P- selectin.
Supercritical carbon dioxide pretreatment of corn stover and switchgrass for lignocellulosic ethanol production.
Sialyl Lewis(x)/E-selectin-mediated rolling in a cell-free system.
Phenyl Methimazole Inhibits TNF-α-Induced VCAM-1 Expression in an IFN Regulatory Factor-1-Dependent Manner and Reduces Monocytic Cell Adhesion to Endothelial Cells1
Results indicate that phenyl methimazole can reduce TNF-α-induced VCAM-1 expression in an IFN regulatory factor-1-dependent manner and that this contributes significantly to reduced monocytic cell adhesion to T NF- α-activated HAEC.
Dynamics of neutrophil rolling over stimulated endothelium in vitro.
PSGL-1 derived from human neutrophils is a high-efficiency ligand for endothelium-expressed E-selectin under flow.
- X. Zou, V. R. Shinde Patil, D. J. Goetz
- BiologyAmerican journal of physiology. Cell physiology
- 1 August 2005
The results support the hypotheses that 1) PSGL-1 is a high-efficiency tethering ligand for E-selectin, 2) ligand biochemistry can significantly influence initial tethering to E- selectin, and 3) PS GL-1 tethering can occur via non-HECA-452 reactive epitopes.
Hyaluronan microspheres for sustained gene delivery and site-specific targeting.
Particle diameter influences adhesion under flow.
Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis.
It is concluded that functional TLR3 are present on thyrocytes;TLR3 downstream signals can be overexpressed by pathogen-related stimuli; overexpression can be reversed by phenylmethimazole to a significantly greater extent than MMI.