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Characterization of the Human Cysteinyl Leukotriene 2 Receptor*
The contractile and inflammatory actions of the cysteinyl leukotrienes (CysLTs), LTC4, LTD4, and LTE4, are thought to be mediated through at least two distinct but related CysLT G protein-coupledExpand
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A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy
Stargardt-like macular dystrophy (STGD3, MIM 600110) and autosomal dominant macular dystrophy (adMD) are inherited forms of macular degeneration characterized by decreased visual acuity, macularExpand
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Cloning and Functional Expression of Two Families of β-Subunits of the Large Conductance Calcium-activated K+ Channel*
We report here a characterization of two families of calcium-activated K+ channel β-subunits, β2 and β3, which are encoded by distinct genes that map to 3q26.2–27. A single β2 family member and fourExpand
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TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development.
A novel CC chemokine was identified in the thymus of mouse and human and was designated TECK (thymus-expressed chemokine). TECK has weak homology to other CC chemokines and maps to mouse chromosomeExpand
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Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R
Melanin-concentrating hormone (MCH) is a 19-aa cyclic neuropeptide originally isolated from chum salmon pituitaries. Besides its effects on the aggregation of melanophores in fish several lines ofExpand
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The Glycine Transporter Type 1 Inhibitor N-[3-(4′-Fluorophenyl)-3-(4′-Phenylphenoxy)Propyl]Sarcosine Potentiates NMDA Receptor-Mediated Responses In Vivo and Produces an Antipsychotic Profile in
Glycine acts as a necessary coagonist for glutamate at the NMDA receptor (NMDAR) complex by binding to the strychnine-insensitive glycine-B binding site on the NR1 subunit. The fact that glycine isExpand
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Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes.
The cysteinyl leukotrienes (CysLTs) are important mediators of human asthma. Pharmacologic and clinical studies show that the CysLTs exert most of their bronchoconstrictive and proinflammatoryExpand
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Urinary biomarkers trefoil factor 3 and albumin enable early detection of kidney tubular injury
The capacities of urinary trefoil factor 3 (TFF3) and urinary albumin to detect acute renal tubular injury have never been evaluated with sufficient statistical rigor to permit their use in regulatedExpand
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Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression.
To assess the contribution of potential central nervous system pathways implicated in the control of appetite regulation and energy metabolism, it is essential to first identify appropriate animalExpand
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The Murine Cysteinyl Leukotriene 2 (CysLT2) Receptor
  • Y. Hui, G. Yang, +6 authors C. Funk
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 14 December 2001
Two classes of cysteinyl leukotriene receptor, CysLT1 and CysLT2, have been identified and pharmacologically characterized in human tissues. Although the CysLT1 receptor mediates the proinflammatoryExpand
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