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The human periodontal ligament cell: a fibroblast-like cell acting as an immune cell.
BACKGROUND Periodontal ligament cells are fibroblast-like cells characterized by collagen production but also possessing some osteoblastic features. In the light of numerous studies presented duringExpand
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Differential effects of estrogen on DNA synthesis in human periodontal ligament and breast cancer cells.
BACKGROUND It is important to clarify the biological function of the female sex hormones estrogen and progesterone in periodontal ligament cells, as these hormones may affect periodontal health. WeExpand
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Differential regulation of chemokine expression by estrogen in human periodontal ligament cells.
BACKGROUND AND OBJECTIVE Estrogen modulates inflammatory responses, but the mechanisms involved have not yet been identified. Periodontal ligament (PDL) cells produce chemokines (a group ofExpand
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Immunocytochemical demonstration of estrogen receptor beta in human periodontal ligament cells.
Two transcription associated estrogen receptor (ER) subtypes have been identified and named ERalpha and ERbeta. In the present study we investigate the expression of these ER subtypes in culturedExpand
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The Antimicrobial Peptide LL-37 Alters Human Osteoblast Ca2+ Handling and Induces Ca2+-Independent Apoptosis
The human antimicrobial peptide cathelicidin LL-37 has, besides its antimicrobial properties, also been shown to regulate apoptosis in a cell type-specific manner. Mechanisms involved inExpand
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LPS induces GROα chemokine production via NF-κB in oral fibroblasts
Objective and designChemotaxis of neutrophils from blood to the inflammation process plays an important role in development of periodontal inflammation. The novel chemokine GROα, also named CXCL1, isExpand
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The antimicrobial peptide LL-37 is anti-inflammatory and proapoptotic in human periodontal ligament cells.
BACKGROUND AND OBJECTIVE The antimicrobial peptide LL-37 is expressed in periodontal tissue, and variations in LL-37 levels have been associated with periodontal disease. The effects of LL-37 onExpand
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1α,25-dihydroxyvitamin D3 promotes osteogenic activity and downregulates proinflammatory cytokine expression in human periodontal ligament cells.
BACKGROUND AND OBJECTIVE The aim of this study was to assess the impact of 1α,25-dihydroxyvitamin D3 (vitamin D3) on osteogenic and inflammatory properties of human periodontal ligament (PDL) cellsExpand
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Effect of micronutrient malnutrition on periodontal disease and periodontal therapy.
Periodontitis is a complex chronic inflammatory noncommunicable disease, initiated by the development of a dysbiotic microbial plaque biofilm below the gingival margin. Whilst the pathogenic biofilmExpand
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Secretory leukocyte protease inhibitor regulates human periodontal ligament cell production of pro-inflammatory cytokines
ObjectiveRegulation of immune-like cell properties of periodontal ligament (PDL) cells is not understood. We investigate the importance of secretory leukocyte protease inhibitor (SLPI) for productionExpand
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