• Publications
  • Influence
Evolution of the cytochrome b gene of mammals.
TLDR
Comparisons of these cytochrome b sequences support current structure-function models for this membrane-spanning protein, which suggests that the outer surface which includes the Qo redox center is more constrained than the remainder of the molecule, namely, the transmembrane segments and the surface that protrudes into the mitochondrial matrix. Expand
Evolution of the cytochromeb gene of mammals
TLDR
Comparisons of these cytochromeb sequences support current structure-function models for this membrane-spanning protein, including that part of the outer surface which includes the Qo redox center is more constrained than the remainder of the molecule, namely, the transmembrane segments and the surface that protrudes into the mitochondrial matrix. Expand
De Novo Origin of Human Protein-Coding Genes
TLDR
RNA–seq data indicate that 60 new protein-coding genes that originated de novo on the human lineage since divergence from the chimpanzee have their highest expression levels in the cerebral cortex and testes, which might suggest that these genes contribute to phenotypic traits that are unique to humans, such as improved cognitive ability. Expand
Whole-genome sequence of the Tibetan frog Nanorana parkeri and the comparative evolution of tetrapod genomes
TLDR
A de novo genome of the Tibetan frog, Nanorana parkeri, is provided and a series of comparisons with other vertebrates are conducted to offer an improved understanding of evolution of tetrapod genomes and also provides a genomic reference for other evolutionary studies. Expand
DNA damage promotes jumping between templates during enzymatic amplification.
TLDR
It was shown that when the thermostable Thermus aquaticus DNA polymerase encounters the end of a template molecule, it sometimes inserts an adenosine residue; the prematurely terminated product then jumps to another template and polymerization continues, creating an in vitro recombination product. Expand
Adaptive evolution of energy metabolism genes and the origin of flight in bats
TLDR
Both mitochondrial and nuclear-encoded OXPHOS genes display evidence of adaptive evolution along the common ancestral branch of bats, supporting the hypothesis that genes involved in energy metabolism were targets of natural selection and allowed adaptation to the huge change in energy demand that were required during the origin of flight. Expand
Draft genome sequence of the Tibetan antelope
  • R. Ge, Qingle Cai, +38 authors Jian Wang
  • Biology, Medicine
  • Nature communications
  • 14 May 2013
TLDR
The genome of the Tibetan antelope shows signals of adaptive evolution and gene-family expansion in genes associated with energy metabolism and oxygen transmission and common genetic mechanisms might have been utilized to enable high-altitude adaptation. Expand
Out of southern East Asia: the natural history of domestic dogs across the world
TLDR
It is found that dogs from southern East Asia have significantly higher genetic diversity compared to other populations, and are the most basal group relating to gray wolves, indicating an ancient origin of domestic dogs in southern EastAsia 33 000 years ago. Expand
CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes.
TLDR
A gene CREPT is reported that is preferentially expressed in diverse human tumors and a mechanism where CREPT increases cyclin D1 transcription during tumorigenesis is revealed, through enhancing the recruitment of RNAPII to the promoter region, possibly as well as chromatin looping. Expand
A profound role for the expansion of trypsin-like serine protease family in the evolution of hematophagy in mosquito.
TLDR
The results suggest that the expansion and diversification of the Tryp_SPc domain family in mosquito was driven by positive selection and helps to explain the adaptive hematophagy of the mosquito. Expand
...
1
2
3
4
5
...