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Pyridones as potential antitumor agents.
Based on the finding that 3-acetoxy-2-pyridone had reproducible activity against murine P-388 lymphocytic leukemia, derivatives in this series were synthesized and evaluated to determine structural…
Pyridones as potential antitumor agents II: 4-Pyridones and bioisosteres of 3-acetoxy-2-pyridone.
- D. Hwang, G. Proctor, J. Driscoll
- Chemistry, BiologyJournal of pharmaceutical sciences
- 1 September 1980
Structural requirements for activity against murine P-388 leukemia have been extended to isosteric analogs of 3-hydroxy-4-pyridone, a compound previously found to have activity, and this compound, which has a T/C value of 179%, is the most active material discovered thus far in the pyridones studies.
Synthesis, Characterization, Kinetic Parameters, and Diagnostic Application of a Sensitive Colorimetric Substrate for β-Galactosidase (2-Chloro-4-Nitrophenyl-β-D-Galactopyranoside)
The synthesis and characterization of 2-chloro-4-nitrophenyl β-D-Galactopyranoside, an improved chromogenic substrate for β-galactosidase, is described, offering at least four times the sensitivity enhancement as that with ortho -nitropenyl β -D- Galactopyrside in the assays forβ-galactsidase.
Synthesis and characterization of digoxin-phospholipid conjugates.
An improved and more efficient synthesis was developed to provide digoxin-phospholipid conjugates useful for liposome immunoassay which involved the linking of the cleaved digitoxose through a carboxymethyl oxime functionality, which provides much improved yields of readily purified products.
1,3,4-oxadiazolin-2-ones from carbo-t-butoxyhydrazones
5-Substituted-1,3,4-oxadiazolin-2-ones 2 were synthesized by the oxidation of carbo-t-butoxyhydrazones 1 of aromatic aldehydes with lead tetraacetate or, preferably, iodosobenzene diacetate. In some…
Synthesis of homopentaprismane and homohypostrophene and some comments on the mechanism of metal ion catalyzed rearrangements of polycyclic compounds
Reactions of amines. 20. Syntheses of racemic and optically active alkylhydrazines and N-acyl-N-alkyl- and N-acyl-N-arylhydrazines
Bei der Behandlung mit Azidokohlensaure-tert.-butylester (II) entsteht aus Phenylhydrazin (I) der Ester (IIIa), der zu (IIIb) benzoyliert wird.
Flow cytometric determination of basophils in whole blood with n-propyl Astra Blue lodide
PYRIDONES AS POTENTIAL ANTITUMOR AGENTS