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Influence of docosahexaenoic acid and cholesterol on lateral lipid organization in phospholipid mixtures.
We investigated lateral lipid organization in membranes with a lipid composition relevant to neural and retinal membranes [phosphatidylcholine (PC)/phosphatidylethanolamine (PE)/phosphatidylserineExpand
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The Potential of Fluorescent and Spin-labeled Steroid Analogs to Mimic Natural Cholesterol*
Cholesterol analogs are often used to investigate lipid trafficking and membrane organization of native cholesterol. Here, the potential of various spin (doxyl moiety) and fluorescentExpand
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Orientation and dynamics of an antimicrobial peptide in the lipid bilayer by solid-state NMR spectroscopy.
The orientation and dynamics of an 18-residue antimicrobial peptide, ovispirin, has been investigated using solid-state NMR spectroscopy. Ovispirin is a cathelicidin-like model peptideExpand
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Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy.
To investigate the structural basis for the antioxidative effects of plant flavonoids on the lipid molecules of cellular membranes, we have studied the location and distribution of five differentExpand
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Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y₂ Receptor Binding and Activation.
Despite recent breakthroughs in the structural characterization of G-protein-coupled receptors (GPCRs), there is only sparse data on how GPCRs recognize larger peptide ligands. NMR spectroscopy,Expand
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Solid-state NMR investigation of the dynamics of the soluble and membrane-bound colicin Ia channel-forming domain.
Solid-state NMR spectroscopy was employed to study the molecular dynamics of the colicin Ia channel domain in the soluble and membrane-bound states. In the soluble state, the protein executesExpand
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Dynamics of Amyloid β Fibrils Revealed by Solid-state NMR*
Background: Alzheimer disease is the most important neurodegenerative disorder; treatment approaches require atomistic knowledge of fibrillar structure and dynamics. Results: We haveExpand
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Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor
Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake, anxiety and cancer biology1,2. The NPY–Y receptor system has emerged asExpand
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Water permeability of polyunsaturated lipid membranes measured by 17O NMR.
Diffusion-controlled water permeation across bilayers of polyunsaturated phospholipids was measured by 17O nuclear magnetic resonance. In 100-nm extruded liposomes containing 50 mM MnCl2, waterExpand
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