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Functional Evaluation of Complete Sciatic, Peroneal, and Posterior Tibial Nerve Lesions in the Rat
Quantification of peripheral nerve regeneration in animal studies of nerve injury and repair by histologic, morphologic, and electrophysiologic parameters has been controversial because such studies… Expand
Walking Track Analysis: A Long‐Term Assessment of Peripheral Nerve Recovery
Functional recovery following sciatic, tibial, and peroneal nerve injury was assessed over a 1-year period using walking track analysis in the rat. Internal neurolysis did not affect nerve function.… Expand
Processed allografts and type I collagen conduits for repair of peripheral nerve gaps
Autografting is the gold standard in the repair of peripheral nerve injuries that are not amenable to end‐to‐end coaptation. However, because autografts result in donor‐site defects and are a limited… Expand
Affinity-based release of glial-derived neurotrophic factor from fibrin matrices enhances sciatic nerve regeneration.
Glial-derived neurotrophic factor (GDNF) promotes both sensory and motor neuron survival. The delivery of GDNF to the peripheral nervous system has been shown to enhance regeneration following… Expand
The effect of duration of muscle denervation on functional recovery in the rat model
The effect of long‐term denervation on neuromuscular recovery was studied in a rat hind limb model. The posterior tibial nerve was transected and repaired immediately or after denervation periods of… Expand
Acellular nerve allografts in peripheral nerve regeneration: A comparative study
Introduction: Processed nerve allografts offer a promising alternative to nerve autografts in the surgical management of peripheral nerve injuries where short deficits exist. Methods: Three… Expand
Schwann Cell Mitochondrial Metabolism Supports Long-Term Axonal Survival and Peripheral Nerve Function
- Andreu Viader, J. Golden, R. Baloh, R. Schmidt, D. Hunter, J. Milbrandt
- Biology, Medicine
- The Journal of Neuroscience
- 13 July 2011
Mitochondrial dysfunction is a common cause of peripheral neuropathies. While the role of neuron and axonal mitochondria in peripheral nerve disease is well appreciated, whether Schwann cell (SC)… Expand
A polymer foam conduit seeded with Schwann cells promotes guided peripheral nerve regeneration.
Alternatives to autografts have long been sought for use in bridging neural gaps. Many entubulation materials have been studied, although with generally disappointing results in comparison with… Expand
Finely Tuned Temporal and Spatial Delivery of GDNF Promotes Enhanced Nerve Regeneration in a Long Nerve Defect Model.
The use of growth factors, such as glial cell line-derived neurotrophic factor (GDNF), for the treatment of peripheral nerve injury has been useful in promoting axon survival and regeneration.… Expand
Binary imaging analysis for comprehensive quantitative histomorphometry of peripheral nerve
- D. Hunter, Arash Moradzadeh, E. L. Whitlock, M. Brenner, S. Mackinnon
- Computer Science, Medicine
- Journal of Neuroscience Methods
- 15 October 2007
This paper introduces a semi-automated binary imaging method for quantitative assessment of myelinated axons in peripheral nerve regeneration following crush, transection, and nerve gap injuries. Expand