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History, challenges and perspectives of cell microencapsulation.
Cell microencapsulation continues to hold significant promise for biotechnology and medicine. The controlled, and continuous, delivery of therapeutic products to the host by immunoisolated cells is aExpand
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An encapsulation system for the immunoisolation of pancreatic islets
Over a thousand combinations of polyanions and polycations were tested to search for new polymer candidates that would be suitable for encapsulation of living cells. The combination of sodiumExpand
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Alginate−Oligochitosan Microcapsules: A Mechanistic Study Relating Membrane and Capsule Properties to Reaction Conditions
A new generation of microcapsules was prepared by utilizing a polyelectrolyte complexation reaction between two oppositely charged polysaccharides, one of which is oligomeric. This capsule combinesExpand
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Rationalizing the design of polymeric biomaterials.
Polymers are a promising class of biomaterials that can be engineered to meet specific end-use requirements. They can be selected according to key 'device' characteristics such as mechanicalExpand
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Maintenance of primary murine hepatocyte functions in multicomponent polymer capsules--in vitro cryopreservation studies.
BACKGROUND/AIMS The potential of a new encapsulation system has been evaluated as an artificial housing for liver cells. METHODS Murine hepatocytes were encapsulated in specially designedExpand
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Encapsulation of Human Islets in Novel Inhomogeneous Alginate-Ca2+/Ba2+ Microbeads: In Vitro and In Vivo Function
Microencapsulation may allow for immunosuppression-free islet transplantation. Herein we investigated whether human islets can be shipped safely to a remote encapsulation core facility and maintainExpand
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Diallyldimethylammonium chloride and its polymers
The pyrrolidimium structure resulting from the cyclopolymerization of the water soluble monomer diallyldimethylammonium chloride is present in a variety of advanced polymeric materials. TheseExpand
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The compressive deformation of multicomponent microcapsules: Influence of size, membrane thickness, and compression speed
The clinical application of microcapsules for the immunoisolation of living tissue requires knowledge about the mechanical stability of polymer membranes. Microcapsules of 400-1000 μm in diameterExpand
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Partial Molar and Specific Volumes of Polyelectrolytes: Comparison of Experimental and Predicted Values in Salt-free Solutions
The partial molar volume, .hivin.V, and the partial sp. vol., .hivin.n, were estd. for more than 25 polyelectrolyte structures. The materials investigated by d. measurements in highly dild. aq.Expand
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Characterization of microcapsules: recommended methods based on round-robin testing
Alginate beads, as well as microcapsules based on alginate, cellulose sulphate and polymethylene-co-guanidine, were produced at diameters of 0.4, 1.0 and 1.5 mm. These standard materials were tested,Expand
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