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An atlas of active enhancers across human cell types and tissues
TLDR
It is shown that enhancers share properties with CpG-poor messenger RNA promoters but produce bidirectional, exosome-sensitive, relatively short unspliced RNAs, the generation of which is strongly related to enhancer activity. Expand
Interferon-gamma: an overview of signals, mechanisms and functions.
TLDR
The current understanding of IFN-gamma ligand, receptor, signal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from other cell types that influence macrophages function during infection are reviewed. Expand
Interferon‐γ: an overview of signals, mechanisms and functions
TLDR
The current understanding of IFN‐γ ligand, receptor, ignal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from other cell types that influence macrophages function during infection are reviewed. Expand
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.
TLDR
A fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression is reported, establishing that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly 6C(-) cells and that the abundance of Ly6 C(+) blood monocytes dynamically controls the circulation lifespan of their progeny. Expand
Genome-wide analysis of mammalian promoter architecture and evolution
TLDR
These tagging methods allow quantitative analysis of promoter usage in different tissues and show that differentially regulated alternative TSSs are a common feature in protein-coding genes and commonly generate alternative N termini. Expand
The Transcriptional Landscape of the Mammalian Genome
TLDR
Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. Expand
The regulated retrotransposon transcriptome of mammalian cells
TLDR
It is reported that 6–30% of cap-selected mouse and human RNA transcripts initiate within repetitive elements, and it is concluded that retrotransposon transcription has a key influence upon the transcriptional output of the mammalian genome. Expand
Antisense Transcription in the Mammalian Transcriptome
TLDR
Experimental evidence that perturbation of an antisense RNA can alter the expression of sense messenger RNAs is presented, suggesting that antisense transcription contributes to control of transcriptional outputs in mammals. Expand
A promoter-level mammalian expression atlas
TLDR
It is found that few genes are truly ‘housekeeping’, whereas many mammalian promoters are composite entities composed of several closely separated TSSs, with independent cell-type-specific expression profiles. Expand
IFITM3 restricts the morbidity and mortality associated with influenza
TLDR
Data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans. Expand
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