D. Hughes

Publications29
h-index10
Citations557
Highly Influential Citations10
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Overt signs of toxicity to dogs and cats of dietary deoxynivalenol.
TLDR
Deoxynivalenol concentration in pet food following manufacture was unchanged, indicating that the toxin was stable during conventional extrusion processing and dogs previously fed DON-contaminated food were able to preferentially select uncontaminatedFood.
Effect of Salbutamol on Respiratory Mechanics in Bronchiolitis
TLDR
Salbutamol failed to produce a beneficial effect on airways in bronchiolitis, but did produce changes in expiration which may be harmful in some infants.
Partial and complete maximum expiratory flow-volume curves in asthmatic patients with spontaneous bronchospasm.
TLDR
Asthmatic patients with spontaneous bronchospasm are only seldom able to obtain bronchodilation following a deep inspiration, and time dependence of maximum expiratory flow due to lung inhomogeneity is concluded.
The effect of oxygen on sleep, blood gases, and ventilation in cystic fibrosis.
TLDR
It is concluded that NLFO is effective in alleviating the nocturnal hypoxemia of patients with CF with stable COPD and does not cause clinically important hypercapnia.
Gastroesophageal reflux during sleep in asthmatic patients.
Effect of compression pressure on forced expiratory flow in infants.
TLDR
Infants with low maximal expiratory flows at low lung volumes required relatively gentle compression to achieve flow limitation and showed decreased flow for firmer compressions and flow-volume curves in each infant tended to become more concave as delta Ppl,c increased.
Shape of forced expiratory flow-volume curves in infants.
TLDR
It is concluded that useful information can be provided from the shape of a partial FEFV curve in an infant, provided that curves are generated by a standardized compression pressure.
Transpulmonary angiotensin II formation in patients with chronic stable cor pulmonale.
TLDR
Administration of oxygen for 30 min led to a small increase in TPAIIFR in the majority of patients, and there was no correlation between serum angiotensin-converting enzyme levels and either the TPA IIFR or the systemic arterial AII concentrations.
Lung function after pertussis
TLDR
The relationship between pertussis infection and subsequent abnormalities of pulmonary function is not clear and standard spirometry, lung volumes by body plethysmography, maximum flows at low lung volumes and histamine challenges were performed.
On the antipyrine test in laboratory animals. Studies in the dog and monkey.
TLDR
For dogs under both basal and induced conditions it is concluded that AP clearance reflects predominantly hepatic AP metabolism, being negligibly influenced by hepatic blood flow.
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