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Cloning and functional characterization of the rat stomach fundus serotonin receptor.
TLDR
A DNA segment homologous to the third exons of the serotonin 1C and 2 receptor genes was isolated from a mouse genomic library and the pharmacological profile resembled that described for the serotonin‐stimulated contraction of the stomach fundus.
(+)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo[1,7- bc][2,6]-naphthyridine: a 5-HT2C/2B receptor antagonist with low 5-HT2A receptor affinity.
TLDR
The indolonaphthyridine 8 is described as a selective 5- HT2C/2B vs 5-HT2A receptor antagonist and behaved as an antagonist on the 5-ht-induced accumulation of inositol phosphates in pig choroid plexus cells.
The role of α2‐adrenoceptor antagonism in the anti‐cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat
TLDR
The present data strongly implicate α2‐adrenoceptor blockade in the anticataleptic properties of clozapine and suggest that its lack of extrapyramidal side effects in the clinic may also be a consequence of this property.
Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L‐745,870 and U‐101958 at human recombinant D4.4 receptors expressed in CHO cells
TLDR
The results show that U‐101958 and L‐745,870 are partial agonists at human dopamine D4.4 receptors expressed in CHO cells, and their efficacy is governed by receptor density.
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