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Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera
The mouse 5-HT2C receptor and its third and fourth (C-terminal) cytoplasmic domain have been expressed as fusion proteins in bacteria. After purification antisera were generated against the fusionExpand
Cloning and functional characterization of the rat stomach fundus serotonin receptor.
A DNA segment homologous to the third exons of the serotonin 1C and 2 receptor genes was isolated from a mouse genomic library. The positions of the introns flanking these exons were conserved in theExpand
(+)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo[1,7- bc][2,6]-naphthyridine: a 5-HT2C/2B receptor antagonist with low 5-HT2A receptor affinity.
The indolonaphthyridine 8 is described as a selective 5-HT2C/2B vs 5-HT2A receptor antagonist. The compound was synthesized in seven steps starting from indoline and isonicotinic acid chloride. TheExpand
The role of α2‐adrenoceptor antagonism in the anti‐cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat
1 The mechanism underlying the anticataleptic properties of the atypical neuroleptic agent, clozapine, has been investigated in the rat. 2 The close structural analogues of clozapine, loxapine (0.1Expand
Chronic mianserin or eltoprazine treatment in rats: effects on the elevated plus-maze test and on limbic 5-HT2C receptor levels.
Rats were chronically treated with mianserin (10 mg/kg i.p.) or eltoprazine (1 mg/kg i.p.) and were tested in the elevated plus-maze test for anxiety. 5-HT2C (previously 5-HT1C, see Humphrey et al.,Expand
The NK1 receptor antagonist NKP608 lacks anxiolytic-like activity in Swiss-Webster mice exposed to the elevated plus-maze
The selective non-peptide NK(1) receptor antagonist NKP608 has been shown to exert potent anxiolytic-like effects in the rat and gerbil social interaction tests. In vitro binding of NKP608 inExpand
SRA880, in vitro characterization of the first non-peptide somatostatin sst(1) receptor antagonist.
This report describes the in vitro features of the first somatostatin sst(1) receptor selective non-peptide antagonist, SRA880 ([3R,4aR,10aR]-1,2,3,4,4a,5,10,10a-Octahydro-6-methoxy-1-methyl-benz[g]Expand
SRA880, in vitro characterization of the first non-peptide somatostatin sst1 receptor antagonist
Abstract This report describes the in vitro features of the first somatostatin sst 1 receptor selective non-peptide antagonist, SRA880Expand
Receptor density as a factor governing the efficacy of the dopamine D4 receptor ligands, L‐745,870 and U‐101958 at human recombinant D4.4 receptors expressed in CHO cells
The relationships between the density of dopamine D4.4 receptors and the agonist efficacies of L‐745,870 (3‐(4‐[4‐chlorophhenyl]piperazin‐1‐yl)‐methyl‐1H‐pyrrolo [2,3‐b]pyridine) and U‐101958Expand
The structure and signalling properties of 5-HT receptors: an endless diversity?
Throughout this symposium there was much speculation on the potential physiological and therapeutic implications of the increasing diversity in structure and signalling properties of 5-HT receptors.Expand
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