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Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations
The updated STAIR preclinical recommendations reinforce the previous suggestions that reproducibly defining dose response and time windows with both histological and functional outcomes in multiple animal species with appropriate physiological monitoring is appropriate.
1,026 Experimental treatments in acute stroke
- V. O'Collins, M. Macleod, G. Donnan, L. Horky, B. van der Worp, D. Howells
- Psychology, MedicineAnnals of neurology
- 1 March 2006
This work endeavored to contrast experimental efficacy and scope of testing of drugs used clinically and those tested only experimentally.
A call for transparent reporting to optimize the predictive value of preclinical research
The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data.
How to increase value and reduce waste when research priorities are set
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) have been updated and information reorganised to facilitate their use in practice to help ensure that researchers, reviewers, and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.
Different Strokes for Different Folks: The Rich Diversity of Animal Models of Focal Cerebral Ischemia
- D. Howells, M. Porritt, M. Macleod
- Biology, PsychologyJournal of cerebral blood flow and metabolism…
- 1 August 2010
The aim is to provide an overview of the key controllable determinants of experimental stroke outcome to help ensure the most effective application of animal models to translational research.
Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy
- E. Sena, H. B. van der Worp, P. Bath, D. Howells, M. Macleod
- Medicine, PsychologyPLoS biology
- 1 March 2010
Publication bias confounds attempts to use systematic reviews to assess the efficacy of various interventions tested in experiments modelling acute ischaemic stroke, leading to a 30% overstatement of…
Can Animal Models of Disease Reliably Inform Human Studies?
H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials and the prospects of doing so in the coming years.
Reduced BDNF mRNA Expression in the Parkinson's Disease Substantia Nigra
If BDNF is an autocrine/paracrine factor for SNpc dopaminergic neurons, loss of BDNF-expressing neurons may compromise the well-being of their surviving neighbors and neurons expressing particularly low levels ofBDNF mRNA may be those at greatest risk of injury in PD and possibly the trigger for the degeneration itself.
Pooling of Animal Experimental Data Reveals Influence of Study Design and Publication Bias
Nicotinamide is a candidate neuroprotective drug with efficacy in experimental stroke, but the limits to and characteristics of that efficacy have not been fully described and meta-analysis provides an effective technique for the aggregation of data from experimental stroke studies.