• Publications
  • Influence
Comparing evolvability and variability of quantitative traits.
TLDR
Measures of variation that are standardized by the trait mean are appropriate for making comparisons of genetic variation for quantitative characters to compare evolvabilities, or ability to respond to selection, and to make inferences about the forces that maintain genetic variability. Expand
The lek paradox and the capture of genetic variance by condition dependent traits
  • L. Rowe, D. Houle
  • Biology
  • Proceedings of the Royal Society of London…
  • 22 October 1996
TLDR
This paper offers a resolution to the lek paradox and rests on only two assumptions; condition dependence of sexually selected traits and high genetic variance in condition, which lead inevitably to the capture of genetic variance into sexually selected trait concomitantly with the evolution of condition dependence. Expand
Measuring and comparing evolvability and constraint in multivariate characters
TLDR
The Lande equation is used to derive new measures of the ability of a variance matrix to allow or constrain evolution in any direction in phenotype space, and these measures are studied to show how they can be used to interpret and compare variance matrices. Expand
PERSPECTIVE: SPONTANEOUS DELETERIOUS MUTATION
TLDR
A broad array of data are reviewed that collectively support the hypothesis that deleterious mutations arise in flies at rate of about one per individual per generation, with the average mutation decreasing fitness by about only 2% in the heterozygous state. Expand
Comparative quantitative genetics : evolution of the G matrix
TLDR
It is proposed that a new field, comparative quantitative genetics, has emerged and the strengths and weaknesses of the many statistical and conceptual approaches now being employed are compared. Expand
Phenomics: the next challenge
TLDR
Phenomics should be recognized and pursued as an independent discipline to enable the development and adoption of high-throughput and high-dimensional phenotyping. Expand
Rates and Genomic Consequences of Spontaneous Mutational Events in Drosophila melanogaster
TLDR
This work sequenced eight genomes produced by a mutation-accumulation experiment in Drosophila melanogaster to estimate genome-wide rates of large deletions and tandem duplications and reveals that point mutation and small indel rates vary significantly between the two different genetic backgrounds examined. Expand
Comparing mutational variabilities.
TLDR
The available data on VM, the amount of genetic variation in phenotypic traits produced each generation by mutation, is reviewed to make several qualitative tests of the mutation-selection balance hypothesis for the maintenance of genetic variance (MSB), and VC/VM approximates the persistence time of mutations under MSB. Expand
Direct Estimation of the Mitochondrial DNA Mutation Rate in Drosophila melanogaster
TLDR
Strand-asymmetric mutation bias, coupled with selection to maintain specific nonsynonymous bases, therefore provides an explanation for the extreme base composition of the mitochondrial genome of Drosophila. Expand
Heritability is not Evolvability
TLDR
The correlation between heritability and evolvability is essentially zero, and it is argued that this is likely due to inherent positive correlations between the additive variance and other components of phenotypic variance. Expand
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