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CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells
In conclusion, inhibition of CIP2A determines the effects of bortezomib on apoptosis and PP2A-dependent Akt inactivation in HCC. Expand
Optically active iridium imidazol-2-ylidene-oxazoline complexes: preparation and use in asymmetric hydrogenation of arylalkenes.
This work explores the potential of iridium complexes of the N-heterocyclic carbene oxazoline ligands 1 in asymmetric hydrogenations of arylalkenes with findings that provide evidence for other types of competing mechanisms that lead to D-incorporation at positions that do not correspond to direct addition to the double bond. Expand
Bortezomib Sensitizes HCC Cells to CS-1008, an Antihuman Death Receptor 5 Antibody, through the Inhibition of CIP2A
It is reported that bortezomib sensitized HCC cells to CS-1008 through the inhibition of CIP2A, and in vivo data showed that CS- 1008 and bortzomib combination treatment decreased tumor growth significantly. Expand
Enantioselective synthesis of (+)-brevipolide H.
This synthesis successfully addresses previous shortcomings in preparing brevipolides and provides the target molecule for cross metathesis in enantioselective fashion. Expand
Chiral imidazolylidine ligands for asymmetric hydrogenation of aryl alkenes.
New, optically active phosphine oxazoline (JM-Phos) ligands: syntheses and applications in allylation reactions.
X-ray crystallographic analysis of the phosphine oxazolines led to the conclusion that the origins of asymmetric induction in these systems might be indirectly attributed to interaction of the oxazoline-phenyl substituent with the palladium and with an allyl- Phenyl Substuent. Expand
Enantioselective hydrogenations of arylalkenes mediated by [Ir(cod) (JM-Phos) ]+ complexes.
In attempts to rationalize why high enantioselectivities were not observed for some alkenes, a series of deuterium labeling experiments were performed to probe for competing reactions that occurred prior to the hydrogenation step. Expand
Cancerous Inhibitor of Protein Phosphatase 2A Mediates Bortezomib-Induced Autophagy in Hepatocellular Carcinoma Independent of Proteasome
It is reported that cancerous inhibitor of protein phosphatase 2A (CIP2A) mediates the apoptotic effect of bortezomib in hepatocellular carcinoma (HCC) and a proteasome-independent mechanism by which bortzomib induces autophagy in HCC through a CIP1-PP2A-Akt-4EBP1 pathway. Expand
Discovery of Novel Agents on Spindle Assembly Checkpoint to Sensitize Vinorelbine-Induced Mitotic Cell Death against Human Non-Small Cell Lung Cancers
YL-9 is a novel agent that synergistically amplifies vinorelbine-induced NSCLC apoptosis through activation of spindle assembly checkpoint and increased mitotic arrest of the cell cycle. Expand
Valproic acid enhances Oct4 promoter activity through PI3K/Akt/mTOR pathway activated nuclear receptors
It is demonstrated that VPA directly activated Oct4 promoter activity through activation of the PI3K/Akt/mTOR signaling pathway that targeted the proximal hormone response element (HRE, -41∼-22) in this promoter. Expand