D. Horrobin

Publications727
h-index75
Citations18,774
Highly Influential Citations465
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A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs.
BACKGROUND In depressed patients, low blood levels of eicosapentaenoic acid are seen. We tested the antidepressive effect of ethyl-eicosapentaenoate in these patients. METHODS We included 70… Expand
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Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients.
BACKGROUND There is a hypothesis that lack of n-3 polyunsaturated fatty acids (PUFAs) is of aetiological importance in depression. Docosahexaenoic acid, a member of the n-3 PUFA family, is a crucial… Expand
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A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms.
The objective was to test effects of ethyl eicosapentaenoate (E-E) on persistent ongoing symptoms in patients receiving different types of anti-schizophrenic drugs, typical antipsychotics, new… Expand
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Depletion of Omega-3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients
BACKGROUND It has been hypothesized that depletion of cell membrane n3 polyunsaturated fatty acids (PUFA), particularly docosahexanoic acid (DHA), may be of etiological importance in depression. … Expand
  • 580
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Nutritional and medical importance of gamma-linolenic acid.
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The philosophical basis of peer review and the suppression of innovation.
Peer review can be performed successfully only if those involved have a clear idea as to its fundamental purpose. Most authors of articles on the subject assume that the purpose of peer review is… Expand
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The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia
  • D. Horrobin
  • Psychology, Materials Science
  • Schizophrenia Research
  • 10 April 1998
The neurodevelopmental hypothesis of schizophrenia is becoming an important feature of research in the field. However, its major drawback is that it lacks any biochemical basis which might draw the… Expand
  • 298
  • 8
Depression and bipolar disorder: relationships to impaired fatty acid and phospholipid metabolism and to diabetes, cardiovascular disease, immunological abnormalities, cancer, ageing and…
Depression and bipolar disorder are two of the commonest illnesses in the developed world. While some patients can be treated effectively with available drugs, many do not respond, especially in the… Expand
  • 231
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Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1β in rats
Central or peripheral administration of the proinflammatory cytokine interleukin (IL)-1β can impair performance on spatial memory tasks and also elevate circulating concentration of corticosterone.… Expand
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A red cell membrane abnormality in a subgroup of schizophrenic patients: evidence for two diseases
There are several reports of abnormalities in fatty acids in brain and blood phospholipids in schizophrenic patients. In order to see if the broad categories of negative and positive schizophrenia… Expand
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