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Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis.
Considering the absolute numbers of apoptotic bodies, their rapid clearance and the dimensions of the small intestinal villi and colonic crypts indicates that the cell loss in the normal murine intestine can largely be explained on the basis of the observed apoptosis.
Oncogenes and onco-suppressor gene in adenocarcinoma of the oesophagus.
It is concluded that errors in the onco-suppressor gene p53, and especially in the external and internal domains of c-erbB2, which is also often expressed in Barrett's mucosa, may be implicated in the development of adenocarcinoma of the oesophagus.
Epidermal growth factor in the oesophagus.
This study has shown that EGF is found only in the endothelial cells of the capillaries of the normal oesophageal mucosa and that the peptide is detectable significantly less frequently than normal in the inflamed oesophysiological mucosa.
Microwave fixation: Its potential for routine techniques, histochemistry, immunocytochemistry and electron microscopy
- D. Hopwood, G. Coghill, J. Ramsay, G. Milne, M. Kerr
- Biology, MedicineThe Histochemical Journal
- 1 November 1984
Human tissues, both biopsy and postmortem, and tissues from rodents were fixed by microwaves at various temperatures and compared against formaldehyde-fixed material, finding the mechanism of fixation appears to be due to denaturation associated with disulphide bond formation and a decrease in solubility of proteins.
The effects of long-term feeding of soya flour on the rat pancreas.
- E. E. McGuinness, R. G. Morgan, D. Levison, D. Frape, D. Hopwood, K. Wormsley
- MedicineScandinavian journal of gastroenterology
Preheating the soya flour seemed to protect against the pancreatic hyperplastic and neoplastic changes.
Proliferating cell nuclear antigen in oesophageal diseases; correlation with transforming growth factor alpha expression.
In glands showing high grade dysplasia, TGF alpha immunoreactivity was seen in the same regions of the glands as PCNA immunore activity, indicating the possibility of involvement of TGFalpha in (pre- neoplastic proliferation in Barrett's oesophagus.
The characterization and energetic potential of brown adipose tissue in man.
Respiratory capacity measurements indicate that the total perinephric fat in adult man can only account for one-fivehundredth of the whole-body response to infused noradrenaline, so considerable caution must be exercised in extrapolating its significance to adult man.
Electron microscopic changes in human oesophageal epithelium in oesophagitis
At the ultrastructural level the inflamed oesophageal epithelium shows a variety of lesions. These include mitochondrial damage, intracellular oedema, membrane whorls and dilation of the endoplasmic…
Cell and tissue fixation, 1972–1982
- D. Hopwood
- MedicineThe Histochemical Journal
- 1 April 1985
There have been changes in the practice of fixation over the past 10 years and it seems that the future will hold increasing diversity in fixation procedures which will demand that practitioners be well informed as to possibilities which may lend to better understanding of the problems and mechanisms of fixation.
Effects of bile acids and hydrogen ion on the fine structure of oesophageal epithelium.
It is concluded that high and moderate concentration of all the common bile acids damaged the oesophagus irrespective of the pH, that low concentrations of bile acid were damaging only at high acid levels, and that damage to the epithelium did not occur when the pH of the gastric juice had been raised.