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Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis.
The regulation of cell number in adult tissues is determined by the balance of cell production and cell loss. In the gastrointestinal tract, where there are well defined zones of proliferation andExpand
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  • 24
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Fixatives and fixation: a review
  • D. Hopwood
  • Biology, Medicine
  • The Histochemical Journal
  • 1 May 1969
ConclusionsDuring the period under review, various new fixatives have been introduced. The most important of these is glutaraldehyde which has become very widely used. The processes involved inExpand
  • 118
  • 5
Theoretical and practical aspects of glutaraldehyde fixation
  • D. Hopwood
  • Chemistry, Medicine
  • The Histochemical Journal
  • 1 July 1972
SynopsisThis review first considers the many structures put forward for glutaraldehyde, and the purification of the commercial material for chemical, histological and histochemical studies. SomeExpand
  • 101
  • 5
Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes.
The single recombinant expressing the Streptomyces coelicolor minimal whiE (spore pigment) polyketide synthase (PKS) is uniquely capable of generating a large array of well more than 30 polyketides,Expand
  • 69
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Oncogenes and onco-suppressor gene in adenocarcinoma of the oesophagus.
While the activation of the proto-oncogenes has been implicated in the development and progression of cancer of many tissues, the role of oncogenes in the development of oesophageal adenocarcinomaExpand
  • 139
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Microwave fixation: Its potential for routine techniques, histochemistry, immunocytochemistry and electron microscopy
SummaryHuman tissues, both biopsy and postmortem, and tissues from rodents were fixed by microwaves at various temperatures and compared against formaldehyde-fixed material. Conventional stains,Expand
  • 72
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The effects of long-term feeding of soya flour on the rat pancreas.
Rats were fed raw and heated soya flour for up to 2 years. The rats fed raw soya flour all developed pancreatic hypertrophy and hyperplastic and adenomatous nodules. Four of 26 rats fed raw soyaExpand
  • 125
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Evidence for hypomotility in non-ulcer dyspepsia: a prospective multifactorial study.
A prospective multifactorial study of symptoms and disturbance of gastrointestinal function has been undertaken in 50 patients with non-ulcer dyspepsia. Objective tests including solid meal gastricExpand
  • 159
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Proliferating cell nuclear antigen in oesophageal diseases; correlation with transforming growth factor alpha expression.
This study was designed to correlate mucosal proliferation in Barrett's oesophagus with expression of a growth promoting peptide, transforming growth factor alpha (TGF alpha). Oesophageal mucosa wasExpand
  • 73
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The characterization and energetic potential of brown adipose tissue in man.
In adult man, brown fat can be detected in perinephric fat depots by visual inspection, electron microscopy and nucleotide binding to the tissue-specific uncoupling protein. The 32 kDa uncouplingExpand
  • 92
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