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What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus
What can be expected in normal aging, and where does normal aging stop and pathological neurodegeneration begin? With the slow progression of age-related dementias such as Alzheimer's disease (AD),Expand
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Brain atrophy in healthy aging is related to CSF levels of Aβ1-42.
Reduced levels of beta-amyloid(1-42) (Abeta1-42) and increased levels of tau proteins in the cerebrospinal fluid (CSF) are found in Alzheimer's disease (AD), likely reflecting Abeta deposition inExpand
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Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis.
PURPOSE To assess whether single-time-point and longitudinal volumetric magnetic resonance (MR) imaging measures provide predictive prognostic information in patients with amnestic mild cognitiveExpand
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Brain Changes in Older Adults at Very Low Risk for Alzheimer's Disease
Alzheimer's disease (AD) has a slow onset, so it is challenging to distinguish brain changes in healthy elderly persons from incipient AD. One-year brain changes with a distinct frontotemporalExpand
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Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-upExpand
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Automated white‐matter tractography using a probabilistic diffusion tensor atlas: Application to temporal lobe epilepsy
Diffusion‐weighted magnetic resonance imaging allows researchers and clinicians to identify individual white matter fiber tracts and map their trajectories. The reliability and interpretability ofExpand
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Genetic overlap between Alzheimer’s disease and Parkinson’s disease at the MAPT locus
We investigated the genetic overlap between Alzheimer’s disease (AD) and Parkinson’s disease (PD). Using summary statistics (P-values) from large recent genome-wide association studies (GWAS) (totalExpand
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Baseline shape diffeomorphometry patterns of subcortical and ventricular structures in predicting conversion of mild cognitive impairment to Alzheimer's disease.
In this paper, we propose a novel predictor for the conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). This predictor is based on the shape diffeomorphometry patterns ofExpand
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Shape abnormalities of subcortical and ventricular structures in mild cognitive impairment and Alzheimer's disease: Detecting, quantifying, and predicting
This article assesses the feasibility of using shape information to detect and quantify the subcortical and ventricular structural changes in mild cognitive impairment (MCI) and Alzheimer's diseaseExpand
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Diffusion-weighted imaging in cancer: physical foundations and applications of restriction spectrum imaging.
Diffusion-weighted imaging (DWI) has been at the forefront of cancer imaging since the early 2000s. Before its application in clinical oncology, this powerful technique had already achievedExpand
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