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In vivo hybridization of technetium-99m-labeled peptide nucleic acid (PNA).
The ability of the PNA to hybridize in vitro with its complement appeared to be unimpaired after conjugation and radiolabeling and 99mTc-PNA displays stability and pharmacokinetic properties suitable for eventual use as radiopharmaceuticals. Expand
Experimental radiation synovectomy by 165Dy ferric hydroxide macroaggregate.
The short half-life beta emitter 165Dy coprecipitated as a macroaggregate with ferric hydroxide (FHMA) has been shown to destroy knee synovium in the antigen-induced arthritic rabbit. Using 153Gd asExpand
Pretargeting using peptide nucleic acid
Pretargeting studies in animals and humans have usually involved (strept)avidin and biotin. Depending on the particular strategy, endogenous biotin can adversely influence localization when theseExpand
Antisense imaging: where are we now?
  • D. Hnatowich
  • Medicine
  • Cancer biotherapy & radiopharmaceuticals
  • 1 October 2000
Estimates showing only low mRNA steady-state copy numbers per cell may be reconsidered in refining predictions of tissue counting rates and recent results suggest that radiolabeling antisense DNAs may not adversely influence the targeting properties of antisenseDNAs. Expand
Myocardial Positron Scintigraphy with Short-Lived 82Rb
Positron-emitting 78-sec 82Rb obtained from a 82Sr (25 day) nuclide generator is used with a multicrystal positron camera for serial non-invasive myocardial scanning and it is concluded that positron scintigraphy with 82R b permits rapid non- invasive assessment of regional myocardIAL perfusion at intervals of several minutes. Expand
Dysprosium-165 ferric hydroxide macroaggregates for radiation synovectomy.
The leakage following injection of the macroaggregates into the knee has been found to be lower than that for gold colloid in the same animal model and the use of a short-lived radionuclide, so that only leakage occurring soon after administration contributes to radiation exposure. Expand
Three-dimensional reconstruction of lung perfusion image with positron detection.
The transverse sections presented demonstrate the capacity of the technique to delineate reduction in regional perfusion resulting from occlusion of the artery to the left lower lobe. Expand
Technetium-99m labeled epidermal growth factor-tumor imaging in mice.
We have shown previously that the epidermal growth factor peptide (EGF) may be radiolabeled with 99mTc at room temperature and neutral pH by using the N-hydroxysuccinimide ester of S-acetylExpand
Technetium-99m antibodies labeled with MAG3 and SHNH: an in vitro and animal in vivo comparison.
For two different antibodies and under the conditions of this study, the MAG3 chelator provided a 99mTc label with properties similar to that of SHNH moiety, with significant differences only in liver (Sandoz) and liver, spleen, intestines, stomach, and blood (C110). Expand
Techniques for positron scintigraphy of the brain.
Six clinical cases are described to illustrate the different cerebral distributions of intravenously administered 68Ga-ATP, 13NH3, and inhaled 15O2. Expand