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Pericontusional brain tissue exhibits persistent elevation of lactate/pyruvate ratio independent of cerebral perfusion pressure*
Objective:To determine whether pericontusional tissue exhibits neurochemical responsiveness to changes in cerebral perfusion pressure as measured by microdialysis lactate/pyruvate ratio.… Expand
Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis
Objective: To determine whether nonconvulsive electrographic post‐traumatic seizures result in increases in intracranial pressure and microdialysis lactate/pyruvate ratio. Design: Prospective… Expand
Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduced levels of extracellular cerebral glutamate and unchanged lactate pyruvate ratios
IntroductionIntracerebral hemorrhage (ICH) is a devastating form of stroke commonly resulting in severe morbidity and high mortality. Secondary brain injury often occurs in the days following the… Expand
Clinical outcomes of middle fossa craniotomy for superior semicircular canal dehiscence repair.
OBJECTIVE Superior semicircular canal dehiscence (SSCD) is a rare disorder characterized by the formation of a third opening in the inner ear between the superior semicircular canal and the middle… Expand
Minimally invasive surgery for lumbar synovial cysts with coexisting degenerative spondylolisthesis
- D. Denis, D. Hirt, Saumya Shah, D. Lu, L. Holly
- International Journal of Spine Surgery
- 24 October 2016
Background About one third of lumbar synovial cysts are associated with degenerative spondylolisthesis. Segmental instability is thought to contribute to the pathogenesis and recurrence of synovial… Expand
Translational Metabolomics of Head Injury: Exploring Dysfunctional Cerebral Metabolism with Ex Vivo NMR Spectroscopy-Based Metabolite Quantification
Metabolomic analysis of cerebral spinal fluid from patients with severe brain injury.
Proton nuclear magnetic resonance (H-NMR) spectroscopic analysis of cerebral spinal fluid provides a quick, non-invasive modality for evaluating the metabolic activity of brain-injured patients. In a… Expand
Role of Metabolomics in Traumatic Brain Injury Research.
- Stephanie M. Wolahan, D. Hirt, Daniel Braas, T. Glenn
- Neurosurgery clinics of North America
- 1 October 2016
Metabolomics is an important member of the omics community in that it defines which small molecules may be responsible for disease states. This article reviews the essential principles of… Expand
Advances in Neurotrauma Research.
th ec li ni cs .c om Traumatic brain injury continues to be the cause of significant morbidity and mortality in the United States and presents numerous challenges, during the acute as well as the… Expand