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Cell-specific radiosensitization by gold nanoparticles at megavoltage radiation energies.
PURPOSE Gold nanoparticles (GNPs) have been shown to cause sensitization with kilovoltage (kV) radiation. Differences in the absorption coefficient between gold and soft tissue, as a function ofExpand
Cross‐bridge detachment and sarcomere 'give' during stretch of active frog's muscle.
1. A study has been made of the tension responses and sarcomere length changes produced by servo‐controlled stretches applied to isometrically contracting frog muscle. Sarcomere lengths wereExpand
Gold nanoparticles as novel agents for cancer therapy.
Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. This review introducesExpand
Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles
Gold nanoparticles (GNPs) are being proposed as contrast agents to enhance X-ray imaging and radiotherapy, seeking to take advantage of the increased X-ray absorption of gold compared to soft tissue.Expand
Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy.
High atomic number (Z) materials such as gold preferentially absorb kilovoltage x-rays compared to soft tissue and may be used to achieve local dose enhancement in tumours during treatment withExpand
The proliferation pattern of a transplantable mouse mammary carcinoma has been studied in relation to its macroscopic and microscopic structure. No significant differences were seen in the labellingExpand
Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy.
BACKGROUND AND PURPOSE The addition of gold nanoparticles (GNPs) to tumours leads to an increase in dose due to their high density and energy absorption coefficient, making it a potentialExpand
Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles
Background This follow-up study aims to determine the physical parameters which govern the differential radiosensitization capacity of two tumor cell lines and one immortalized normal cell line toExpand
Transcriptional Targeting in Cancer Gene Therapy
Cancer gene therapy has been one of the most exciting areas of therapeutic research in the past decade. In this review, we discuss strategies to restrict transcription of transgenes to tumour cells.Expand
Inhibition of PARP-1 by Olaparib (AZD2281) Increases the Radiosensitivity of a Lung Tumor Xenograft
PARP-1 is a critical enzyme in the repair of DNA strand breaks. Inhibition of PARP-1 increases the effectiveness of radiation in killing tumor cells. However, although the mechanism(s) are wellExpand