• Publications
  • Influence
High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability
TLDR
The hypothesis that stem‐like cells play a key role in metastatic behaviour in breast cancer metastasis is tested and novel results suggest that stem-cell‐like ALDHhiCD44+CD24− and ALDHHICD44-CD133+ cells may be important mediators of breast cancer tumours metastasis.
Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity.
TLDR
Cell fractionation according to lineage depletion and ALDH activity provides a viable and prospective purification of HSCs on the basis of cell function rather than cell surface phenotype.
Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells.
TLDR
Cell selection based on ALDH activity and CD133 expression provides a novel purification of HSCs with long-term repopulating function and may be considered an alternative to CD34 cell selection for stem cell therapies.
Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells.
TLDR
The exocrine pancreas of adult mice can be remodeled by re-expression of the transcription factor MIST1, which regulates acinar cell maturation and might be used to repair damaged pancreata in patients with pancreatic disorders.
Functional analysis of human hematopoietic repopulating cells mobilized with granulocyte colony-stimulating factor alone versus granulocyte colony-stimulating factor in combination with stem cell
TLDR
This study defines qualitative and quantitative distinctions among subsets of primitive cells mobilized by means of G-CSF plus SCF versus G- CSF alone, and therefore has implications for the utility of purified repopulating cells from these sources.
COX-2 Elevates Oncogenic miR-526b in Breast Cancer by EP4 Activation
TLDR
Novel findings are presented that miRNA 526b is a COX-2 upregulated, oncogenic miRNA promoting SLCs, the expression of which follows EP4 receptor-mediated signaling, and is a promising biomarker for monitoring and personalizing breast cancer therapy.
Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity.
TLDR
Human BM ALDH(hi) cells represent a progenitor-enriched population of several cell lineages that improves perfusion in ischemic limbs after transplantation that may prove useful in the treatment of critical ischemia in humans.
Concise Review: Cell Therapy for Critical Limb Ischemia: An Integrated Review of Preclinical and Clinical Studies
TLDR
Combined delivery of multiple cell types within supportive bioengineered matricies may represent a new direction to improve cell therapy strategies for critical limb ischemia.
Haptenation of sulfonamide reactive metabolites to cellular proteins.
TLDR
Sulfonamide-specific haptens were rapidly internalized by what seemed to be a caveolae-dependent process and it seems that sulfonamide reactive metabolites haptenated specific cell surface proteins that are rapidlyinternalized.
...
1
2
3
4
5
...