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High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability
- Alysha K Croker, David Goodale, +4 authors A. Allan
- Biology, Medicine
- Journal of cellular and molecular medicine
- 1 August 2009
Cancer stem cells (CSCs) have recently been identified in leukaemia and solid tumours; however, the role of CSCs in metastasis remains poorly understood. This dearth of knowledge about CSCs and… Expand
Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity.
Human hematopoietic stem cells (HSCs) are commonly purified by the expression of cell surface markers such as CD34. Because cell phenotype can be altered by cell cycle progression or ex vivo culture,… Expand
Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells.
The development of novel cell-based therapies requires understanding of distinct human hematopoietic stem and progenitor cell populations. We recently isolated reconstituting hematopoietic stem cells… Expand
Functional analysis of human hematopoietic repopulating cells mobilized with granulocyte colony-stimulating factor alone versus granulocyte colony-stimulating factor in combination with stem cell…
Using in vitro progenitor assays, serum-free in vitro cultures, and the nonobese diabetic/severe combined immune-deficient (NOD/SCID) ecotropic murine virus knockout xenotransplantation model to… Expand
Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells.
BACKGROUND & AIMS Early embryogenesis involves cell fate decisions that define the body axes and establish pools of progenitor cells. Development does not stop once lineages are specified; cells… Expand
COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis.
Cancer stem-like cells (SLC) resist conventional therapies, necessitating searches for SLC-specific targets. We established that cyclo-oxygenase(COX)-2 expression promotes human breast cancer… Expand
Lateralized caudate metabolic abnormalities in adolescent major depressive disorder: a proton MR spectroscopy study.
- V. Gabbay, D. Hess, S. Liu, J. Babb, R. Klein, O. Gonen
- Medicine, Psychology
- The American journal of psychiatry
- 1 December 2007
OBJECTIVE Proton magnetic resonance spectroscopy ((1)H-MRS) has been increasingly used to examine striatal neurochemistry in adult major depressive disorder. This study extends the use of this… Expand
Human progenitor cells rapidly mobilized by AMD3100 repopulate NOD/SCID mice with increased frequency in comparison to cells from the same donor mobilized by granulocyte colony stimulating factor.
- D. Hess, J. Bonde, +7 authors J. Nolta
- Biology of blood and marrow transplantation…
- 1 April 2007
AMD3100 inhibits the interaction between SDF-1 and CXCR4, and rapidly mobilizes hematopoietic progenitors for clinical transplantation. However, the repopulating function of human cells mobilized… Expand
Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in mice.
- D. Hess, Sean E. Humphrey, +4 authors S. F. Konieczny
- Medicine, Biology
- 1 October 2011
BACKGROUND & AIMS Progression of diseases of the exocrine pancreas, which include pancreatitis and cancer, is associated with increased levels of cell stress. Pancreatic acinar cells are involved in… Expand
COX-2 Elevates Oncogenic miR-526b in Breast Cancer by EP4 Activation
- Mousumi Majumder, Erin Landman, Ling Liu, D. Hess, P. Lala
- Biology, Medicine
- Molecular Cancer Research
- 2 March 2015
MicroRNAs (miRs) are small regulatory molecules emerging as potential biomarkers in cancer. Previously, it was shown that COX-2 expression promotes breast cancer progression via multiple mechanisms,… Expand