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A genomic storm in critically injured humans
It is shown that critical injury in humans induces a genomic storm with simultaneous changes in expression of innate and adaptive immunity genes that alter the status of these genes in the immune system. Expand
Genomic responses in mouse models poorly mimic human inflammatory diseases
This study shows that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another. Expand
Hydrogen sulfide is an endogenous stimulator of angiogenesis
Investigation of the role of exogenous and endogenous hydrogen sulfide on neovascularization and wound healing in vitro and in vivo concludes that endogenous and exogenous H2S stimulates EC-related angiogenic properties through a KATP channel/MAPK pathway. Expand
American Burn Association Consensus Conference to Define Sepsis and Infection in Burns
The goal of the consensus conference was to develop and publish standardized definitions for sepsis and infection-related diagnoses in the burn population, which will improve the capability of performing more meaningful multicenter trials among burn centers. Expand
Objective Assessment of Burn Scar Vascularity, Erythema, Pliability, Thickness, and Planimetry
Objective rating systems using reliable instruments can be used to replace subjective scar assessment and replace each clinical parameter of a clinical scar scale by objective measurements. Expand
Long-Term Persistance of the Pathophysiologic Response to Severe Burn Injury
Severe burn injury leads to a much more profound and prolonged hypermetabolic and hyperinflammatory response than previously shown, and treatment needs for severely burned patients for a muchMore prolonged time are identified. Expand
Reversal of catabolism by beta-blockade after severe burns.
In children with burns, treatment with propranolol during hospitalization attenuates hypermetabolism and reverses muscle-protein catabolism. Expand
Respiratory management of inhalation injury.
Inhalation injury has now become the most frequent cause of death in burn patients and a well organized, protocol driven approach to respiratory care of inhalation injury is needed so that improvements can be made and the morbidity and mortality associated with inhalation injuries be reduced. Expand
Current treatment of severely burned patients.
OBJECTIVE The authors provide an update on a multidisciplinary approach to the treatment of severely burned patients. A review of studies and clinical trials from the past to the present includeExpand
Emerging infections in burns.
Innovations in fluid management, ventilatory support, surgical care, and antimicrobial therapy have contributed to a significant reduction in morbidity and mortality rates in burn patients. Expand