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Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements.
TLDR
It is hypothesized that automatic spike-sorting algorithms have the potential to significantly lower error rates, and implementation of a semi-automatic classification system confirms this suggestion, reducing errors close to the estimated optimum, in the range 0-8%. Expand
Intracellular features predicted by extracellular recordings in the hippocampus in vivo.
TLDR
A large percentage of hippocampal CA1 pyramidal cells are silent in any given behavioral condition, and it is determined that a tetrode in hippocampal area CA1 theoretically should be able to record electrical signals from approximately 1, 000 neurons. Expand
Quantitative measures of cluster quality for use in extracellular recordings
TLDR
In data sets from the rodent hippocampus in which neurons were simultaneously recorded intracellularly and extracellularly, values of Isolation Distance and Lratio were related to the correct identification of spikes. Expand
Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo
TLDR
It is suggested that information in single granule cells is converted into a temporal delay code in target CA3 pyramidal cells and interneurons and reduced the delay between the onset of a granule cell train and evoked firing in postsynaptic targets. Expand
On the origin of the extracellular action potential waveform: A modeling study.
TLDR
A model system that captures features of experimentally recorded simultaneous intracellular and extracellular recordings of CA1 pyramidal neurons and demonstrates that the varied composition of ionic currents in different cells is reflected in the features of the EAP. Expand
The multifarious hippocampal mossy fiber pathway: a review
TLDR
It is suggested that understanding the functional role of the hippocampusal mossy fiber pathway may lie in an appreciation of its variety of unique properties that make it a strong yet broadly modulated synaptic input to postsynaptic targets in the hilus of the dentate gyrus and area CA3 of the hippocampal formation. Expand
Temporal Interaction between Single Spikes and Complex Spike Bursts in Hippocampal Pyramidal Cells
TLDR
It is suggested that bursts may function as "conditional synchrony detectors," signaling strong afferent synchrony after neuronal silence, and that single spikes triggered by a weak input may suppress bursts evoked by a subsequent strong input. Expand
Integration and Segregation of Activity in Entorhinal-Hippocampal Subregions by Neocortical Slow Oscillations
TLDR
In anesthetized rats, neocortical "slow" oscillation engages neurons in prefrontal, somatosensory, entorhinal, and subicular cortices into synchronous transitions between UP and DOWN states, with a corresponding bimodal distribution of their membrane potential. Expand
HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity
TLDR
Using oral administration of the selective TRPA1 antagonist HC-030031, the results demonstrated that TRPA 1 plays an important role in the mechanisms responsible for mechanical hypersensitivity observed in inflammatory and neuropathic pain models and suggested thatTRPA1 antagonism may be a suitable new approach for the development of a potent and selective therapeutic agent to treat both inflammatory and Neuropathic pain. Expand
Spike train dynamics predicts theta-related phase precession in hippocampal pyramidal cells
TLDR
It is suggested that intrinsic properties of pyramidal cells have a key role in determining spike times, and that the interplay between the magnitude of dendritic excitation and rhythmic inhibition of the somatic region is responsible for the phase assignment of spikes. Expand
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