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The kinetics of triclabendazole disposition in sheep.
To investigate whether the disposition of triclabendazole (TCBZ) and its metabolites in blood or bile influenced its flukicidal potency, TCBZ was administered intraruminally at 10 mg kg-1 to sheep
The disposition of albendazole in sheep.
Albendazole (ABZ) was administered intraruminally to sheep fitted with a permanent bile-duct cannula to determine if its metabolites might contribute to its flukicidal action and it is suggested that ABZ is sequestered in the liver.
Physiology, pharmacology and parasitology.
  • D. Hennessy
  • Biology, Medicine
    International journal for parasitology
  • 1 February 1997
Careful administration, coupled with a reduction of feed intake before oral anthelmintic treatment, maximises drug availability and therefore increases efficacy of the benzimidazole and ivermectin compounds, which will be instrumental in prolonging the useful life of the newer drugs.
Prolonged administration: A new concept for increasing the spectrum and effectiveness of anthelmintics
The magnitude and duration of concentrations of TBZ, FBZ and OFZ in plasma and other body compartments after administration were compared with their effectiveness against parasites, and the spectrum and effectiveness of benzimidazoles may be improved by extending the period during which parasites are exposed to toxic concentrations.
Comparative pharmacokinetic behaviour of albendazole in sheep and goats.
Albendazole (ABZ) containing a trace of [14C]-ABZ was administered intraruminally at 4.75 mg kg-1 to Merino sheep and Angora goats and the pharmacokinetic behaviour of ABZ and its metabolites in
Disposition of oxfendazole in goats and efficacy compared with sheep.
When given at this rate as a divided dose at 12 hourly intervals over 24 hours, OFZ was significantly more effective than a single dose in reducing egg counts, and a dose rate of 10 mg kg-1 is recommended for goats.
The disposition of antiparasitic drugs in relation to the development of resistance by parasites of livestock.
It is anticipated that a greater understanding of the physiological/pharmacological effects which are described in this review will permit the more efficient use of existing and future antiparasitic drugs.
Comparative kinetic disposition of oxfendazole in sheep and goats before and during infection with Haemonchus contortus and Trichostrongylus colubriformis.
It is suggested that goats possess a faster hepatic metabolism than sheep resulting in more rapid elimination of OFZ, and the elimination of plasma [14C] was faster in goats than in sheep.
Cholecystokinin and anorexia in sheep infected by the intestinal nematode Trichostrongylus colubriformis.
It was concluded that anorexia in these infections may be due to or be mediated by higher concentrations of CCK.