D. Hellhammer

Publications295
h-index84
Citations37,310
Highly Influential Citations2,005
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The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting.
This paper describes a protocol for induction of moderate psychological stress in a laboratory setting and evaluates its effects on physiological responses. The 'Trier Social Stress Test' (TSST)… Expand
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The cortisol awakening response - normal values and confounds.
In several recent investigations it could be demonstrated that the free cortisol response to awakening can serve as an useful index of the adrenocortical activity. When measured with strict reference… Expand
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Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis.
OBJECTIVE Results from animal and human studies suggest that disregulations of the hypothalamus-pituitary-adrenal (HPA) axis are involved in several behavioral, circulatory, endocrine, and immune… Expand
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Free cortisol levels after awakening: a reliable biological marker for the assessment of adrenocortical activity.
In three independent studies, free cortisol levels after morning awakening were repeatedly measured in children, adults and elderly subjects (total n=152). Cortisol was assessed by sampling saliva at… Expand
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The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders
Representing a challenge for current concepts of stress research, a number of studies have now provided convincing evidence that the adrenal gland is hypoactive in some stress-related states. The… Expand
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Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change
Study protocols in endocrinological research and the neurosciences often employ repeated measurements over time to record changes in physiological or endocrinological variables. While it is desirable… Expand
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Salivary cortisol in psychoneuroendocrine research: Recent developments and applications
The assessment of cortisol in saliva has proven a valid and reliable reflection of the respective unbound hormone in blood. To date, assessment of cortisol in saliva is a widely accepted and… Expand
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Salivary cortisol in psychobiological research: an overview.
The measurement of cortisol in saliva provides the basic scientist as well as the clinician with a reliable tool for investigations of hypothalamus-pituitary-adrenal axis activity. Since saliva… Expand
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Attenuated Free Cortisol Response to Psychosocial Stress in Children with Atopic Dermatitis
Objective Atopic dermatitis (AD) is an inflammatory skin disease characterized by a hyperactivity of the humoral immune system with an onset in infancy or early childhood. Although most of the… Expand
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Genetic factors, perceived chronic stress, and the free cortisol response to awakening
Recent studies have demonstrated that the free cortisol response to awakening can serve as a useful index of hypothalamus-pituitary-adrenal axis (HPA) activity. This endocrine marker is rather… Expand
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