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Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors.
Variations in the intracellular levels of antagonistic splicing factors influence different modes of alternative splicing in vivo and may be a natural mechanism for tissue-specific or developmental regulation of gene expression. Expand
Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions.
A role for nonmuscle caldesmon in the physiological regulation of actomyosin contractility and adhesion-dependent signaling is indicated and the involvement of contractility in focal adhesion formation is demonstrated. Expand
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility
Evidence is presented that RSK1 drives p27 phosphorylation at T198 to increase RhoA-p27 binding and cell motility, and that T198 phosphorylated p27 not only stabilizes p27 and mislocalized p27 to the cytoplasm but also promotes RHoA- p27 interaction and Rho a pathway inhibition. Expand
A new tropomyosin essential for cytokinesis in the fission yeast S. pombe
Results indicate that cdc8 tropomyosin has a specialized role which, it is suggested, is to form part of the F-actin contractile ring at cytokinesis. Expand
The molecular basis for tropomyosin isoform diversity
The tropomyosins are a family of actin filament binding proteins that exhibit extensive cell type specific isoform diversity and their possible significance to cellular function is discussed. Expand
Cytoskeletal changes in cell transformation and tumorigenesis.
Experiments show that the cytoskeleton plays a critical role in the regulation of various cellular processes linked to transformation including proliferation, contact inhibition, anchorage-independent cell growth, and apoptosis. Expand
Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene.
Results indicate that hnRNP H participates in exclusion of exon 7 in nonmuscle cells and may represent a prototype for the regulation of tissue- and developmental-specific alternative splicing. Expand
Functional properties of non-muscle tropomyosin isoforms.
Tropomyosins are a family of actin filament binding proteins identified in many organisms, including yeast, nematodes, Drosophila, birds and mammals. Expand
Cytoplasmic p21Cip1 Is Involved in Ras-induced Inhibition of the ROCK/LIMK/Cofilin Pathway*
The results suggest that restoration of cofilin phosphorylation in Ras-transformed cells is necessary but not sufficient for stress fiber formation and suggest that localization of p21Cip1 to the cytoplasm in transformed cells contributes to pathways that favor not only cell proliferation, but also cell motility thereby contributing to invasion and metastasis. Expand
The metastasis associated protein S100A4: role in tumour progression and metastasis
The metastasis associated protein S100A4 is a small calcium binding protein that is associated with metastatic tumors and appears to be a molecular marker for clinical prognosis. Below we discuss itsExpand