• Publications
  • Influence
Regulation of the cerebral circulation: role of endothelium and potassium channels.
Several new concepts have emerged in relation to mechanisms that contribute to regulation of the cerebral circulation. This review focuses on some physiological mechanisms of cerebral vasodilatationExpand
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Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive
Calcific aortic valve disease (CAVD) encompasses the range of disease from initial alterations in the cell biology of the leaflets to end-stage calcification resulting in left ventricular outflowExpand
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Regulation of large cerebral arteries and cerebral microvascular pressure.
Resistance of large arteries appears to be greater in the cerebral circulation than in other vascular beds. Large arteries contribute importantly to total cerebral vascular resistance and are majorExpand
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Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia.
Hyperhomocyst(e)inemia is associated with endothelial dysfunction. Mechanisms responsible for endothelial dysfunction in hyperhomocyst(e)inemia may involve impaired bioavailability ofExpand
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Calcific Aortic Valve Stenosis: Methods, Models, and Mechanisms
Calcific aortic valve stenosis (CAVS) is a major health problem facing aging societies. The identification of osteoblast-like and osteoclast-like cells in human tissue has led to a major paradigmExpand
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Oxidative stress and vascular disease: 2005 Duff lecture.
  • D. Heistad
  • Medicine
  • Arteriosclerosis, thrombosis, and vascular…
  • 1 April 2006
There is compelling evidence that oxidative stress plays a key role in the pathophysiology of several major cardiovascular diseases. In atherosclerosis, hypertension, stroke, diabetes, and heartExpand
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Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis.
The endothelium is a source of reactive oxygen species in short-term models of hypercholesterolemia and atherosclerosis. We examined a chronic model of atherosclerosis for increased vascularExpand
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The role of low pressure baroreceptors in reflex vasoconstrictor responses in man.
Studies were performed on 11 healthy men to evaluate the role of low pressure baroreceptors in the reflex forearm vasoconstrictor responses (plethysmography) to venous pooling produced by lower bodyExpand
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Novel aspects of oxidative stress in cardiovascular diseases.
Oxygen radicals, and other reactive oxygen species, may play an important role in the pathophysiology of atherosclerosis, stroke, and other cardiovascular diseases. Mechanisms that account forExpand
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Depression of ventilation by dopamine in man. Evidence for an effect on the chemoreceptor reflex.
Dopamine is present in the carotid body and has been postulated to be an inhibitory neurotransmitter. The purpose of this study was to determine the effects of dopamine on ventilation in man and toExpand
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