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The human genome browser at UCSC.
As vertebrate genome sequences near completion and research refocuses to their analysis, the issue of effective genome annotation display becomes critical. A mature web tool for rapid and reliable… Expand
Initial sequencing and analysis of the human genome.
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and… Expand
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes.
We have conducted a comprehensive search for conserved elements in vertebrate genomes, using genome-wide multiple alignments of five vertebrate species (human, mouse, rat, chicken, and Fugu… Expand
Integrative analysis of 111 reference human epigenomes
The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the… Expand
GENCODE: the reference human genome annotation for The ENCODE Project.
- J. Harrow, A. Frankish, +38 authors Tim J. P. Hubbard
- Biology, Medicine
- Genome research
- 1 September 2012
The GENCODE Consortium aims to identify all gene features in the human genome using a combination of computational analysis, manual annotation, and experimental validation. Since the first public… Expand
The Somatic Genomic Landscape of Glioblastoma
We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated… Expand
The UCSC Table Browser data retrieval tool
The University of California Santa Cruz (UCSC) Table Browser (http://genome.ucsc.edu/cgi-bin/hgText) provides text-based access to a large collection of genome assemblies and annotation data stored… Expand
Learnability and the Vapnik-Chervonenkis dimension
- A. Blumer, A. Ehrenfeucht, D. Haussler, Manfred K. Warmuth
- Computer Science, Mathematics
- 1 October 1989
Valiant's learnability model is extended to learning classes of concepts defined by regions in Euclidean space En. The methods in this paper lead to a unified treatment of some of Valiant's results,… Expand
Exploiting Generative Models in Discriminative Classifiers
Generative probability models such as hidden Markov models provide a principled way of treating missing information and dealing with variable length sequences. On the other hand, discriminative… Expand
Integrated genomic characterization of endometrial carcinoma
- D. Levine, Gad Stacey B. Kristian Eric Andrey Carrie Mike Cyriac Getz Gabriel Cibulskis Lander Sivachenko Sougnez L, +271 authors H. Sofia
- Medicine, Biology
- 1 May 2013
We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ∼25% of… Expand