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PDA‐TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate‐to‐Large Patent Ductus Arteriosus at 1 Week of Age
In preterm infants age <28 weeks with moderate‐to‐large PDAs who were receiving respiratory support after the first week, ERT did not reduce PDA ligations or the presence of a PDA at discharge and did not improve any of the prespecified secondary outcomes, but delayed full feeding and was associated with higher rates of late‐onset sepsis and death. Expand
Enteral feeding during indomethacin and ibuprofen treatment of a patent ductus arteriosus.
Infants required less time to reach the feeding volume end point if they were given "trophic" enteral feedings when they received indomethacin or ibuprofen treatment for patent ductus arteriosus. Expand
Prolonged tracheal intubation and the association between patent ductus arteriosus and bronchopulmonary dysplasia: a secondary analysis of the PDA-TOLERATE trial.
In the PDA-TOLERATE trial, persistent (even for several weeks) moderate to large patent ductus arteriosus (PDA) was not associated with an increased risk of BPD when the infant required <10 days of… Expand
Evaluation of critical congenital heart defects screening using pulse oximetry in the neonatal intensive care unit
Given the majority of NICU infants were ⩾2500 g, not on oxygen and not preidentified for CCHD, systematic screening at 24 to 48 h may be of benefit for early detection of CCHd with minimal burden. Expand
Longitudinal Changes of Brain-Type Natriuretic Peptide in Preterm Neonates
Comparisons revealed that the size of the patent ductus arteriosus was the major determinant of both brain-type natriuretic peptide levels and the degree of ventilatory support in preterm infants. Expand
Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320)
Indomethacin was more effective than acetaminophen in producing ductus constriction in newborns and compared with spontaneous constriction during Conservative management. Expand
Lack of Equipoise in the PDA-TOLERATE Trial: A Comparison of Eligible Infants Enrolled in the Trial and Those Treated Outside the Trial.
The PDA: TO LEave it alone or Respond And Treat Early trial compared the effects of 2 strategies for treatment of patent ductus arteriosus (PDA) in infants <280/7 weeks of gestation; however 137… Expand