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Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells
It is found that cytoplasmic vacuoles induced in pancreatic acinar cells by experimental pancreatitis were autophagic in origin, as demonstrated by microtubule-associated protein 1 light chain 3 expression and electron microscopy experiments, and trypsinogen activation was greatly reduced in the absence of autophagy.
Applicability of Disseminated Intravascular Coagulation Parameters in the Assessment of the Severity of Acute Pancreatitis
The aggravated coagulation parameters predict a fatal outcome in patients with acute pancreatitis, and an AT-III value of 69% at admission was the best cut-off value to predict fatal outcome.
Tumour-infiltrating inflammatory and immune cells in patients with extrahepatic cholangiocarcinoma
The data showed that tumour infiltrating inflammatory and immune cells may play a pivotal role in ECC progression and a high-risk signature predicted poor prognosis in E CC patients.
Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs.
An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell-like Behaviors Contributing to Disease Progression.
It is demonstrated that TAZ and YAP exhibit different functional roles in cancer progression, and a shift to predominant YAP expression upon TAZ depletion conferred cancer stem cell-like properties including chemoresistance and tumorigenicity in HCC.
Pancreatic cancer in the remnant pancreas following primary pancreatic resection
The results suggest that both local recurrence and a new primary cancer can develop in the pancreatic remnant, and repeated pancreatectomy can prolong survival.
Effects of Preoperative Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios on Survival in Patients with Extrahepatic Cholangiocarcinoma.
High preoperative PLR was an independent predictor of poor prognosis for patients with ECC who underwent resections as well as independent prognostic factors for OS.
Percentage of Future Liver Remnant Volume Before Portal Vein Embolization Influences the Degree of Liver Regeneration After Hepatectomy
After PVE and the subsequent hepatectomy, liver regeneration was accomplished in a two-step manner and Liver regeneration was strongly influenced by the %FLR-pre.
Enhancer of Zeste Homolog 2 (EZH2) Promotes Progression of Cholangiocarcinoma Cells by Regulating Cell Cycle and Apoptosis
The current study demonstrated relationships between EZH2 expression and acceleration of the cell cycle and antiapoptosis, and poor prognosis in cholangiocarcinoma.
CD44s signals the acquisition of the mesenchymal phenotype required for anchorage-independent cell survival in hepatocellular carcinoma
CD44s symbolises the acquisition of a mesenchymal phenotype regulating anchorage-independent capacity and CD44s-expressing tumour cells in peripheral blood are clinically important therapeutic targets in HCC.