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Secretory IgA N- and O-Glycans Provide a Link between the Innate and Adaptive Immune Systems*
Secretory IgA (SIgA) is a multi-polypeptide complex consisting of a secretory component (SC) covalently attached to dimeric IgA containing one joining (J) chain. We present the analysis of both theExpand
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Matrix-assisted laser desorption/ionization mass spectrometry of carbohydrates.
  • D. Harvey
  • Chemistry, Medicine
  • Mass spectrometry reviews
  • 1999
This review describes the application of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry to carbohydrate analysis and covers the period 1991-1998. The technique is particularlyExpand
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Function and glycosylation of plant-derived antiviral monoclonal antibody
Plant genetic engineering led to the production of plant-derived mAb (mAbP), which provides a safe and economically feasible alternative to the current methods of antibody production in animalExpand
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Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens
The envelope spike of HIV is one of the most highly N-glycosylated structures found in nature. However, despite extensive research revealing essential functional roles in infection and immuneExpand
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Sequencing of N-linked oligosaccharides directly from protein gels: in-gel deglycosylation followed by matrix-assisted laser desorption/ionization mass spectrometry and normal-phase high-performance
A generally applicable, rapid, and sensitive method for profiling and sequencing of glycoprotein-associated N-linked oligosaccharides from protein gels was developed. The method employed sodiumExpand
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Glycosylation differences between the normal and pathogenic prion protein isoforms.
  • P. Rudd, T. Endo, +8 authors R. Dwek
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 9 November 1999
Prion protein consists of an ensemble of glycosylated variants or glycoforms. The enzymes that direct oligosaccharide processing, and hence control the glycan profile for any given glycoprotein, areExpand
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Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG.
Ovarian cancer is the fourth most common cancer in women in the Western world. In a pilot scale study, we highlight changes in the total serum glycome of patients with advanced ovarian cancer thatExpand
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Altered glycosylation pattern allows the distinction between prostate-specific antigen (PSA) from normal and tumor origins.
Prostate-specific antigen (PSA) is a glycoprotein secreted by prostate epithelial cells. PSA is currently used as a marker of prostate carcinoma because high levels of PSA are indicative of a tumorExpand
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Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity.
While the induction of a neutralizing antibody response against HIV remains a daunting goal, data from both natural infection and vaccine-induced immune responses suggest that it may be possible toExpand
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Complement regulation at the molecular level: the structure of decay-accelerating factor.
The human complement regulator CD55 is a key molecule protecting self-cells from complement-mediated lysis. X-ray diffraction and analytical ultracentrifugation data reveal a rod-like arrangement ofExpand
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