D. Harvey

Publications458
h-index75
Citations19,710
Highly Influential Citations593
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Secretory IgA N- and O-Glycans Provide a Link between the Innate and Adaptive Immune Systems*
Secretory IgA (SIgA) is a multi-polypeptide complex consisting of a secretory component (SC) covalently attached to dimeric IgA containing one joining (J) chain. We present the analysis of both the… Expand
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Matrix-assisted laser desorption/ionization mass spectrometry of carbohydrates.
  • D. Harvey
  • Chemistry, Medicine
  • Mass spectrometry reviews
  • 1999
This review describes the application of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry to carbohydrate analysis and covers the period 1991-1998. The technique is particularly… Expand
  • 567
  • 16
  • PDF
Function and glycosylation of plant-derived antiviral monoclonal antibody
Plant genetic engineering led to the production of plant-derived mAb (mAbP), which provides a safe and economically feasible alternative to the current methods of antibody production in animal… Expand
  • 234
  • 14
  • PDF
Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens
The envelope spike of HIV is one of the most highly N-glycosylated structures found in nature. However, despite extensive research revealing essential functional roles in infection and immune… Expand
  • 279
  • 14
Sequencing of N-linked oligosaccharides directly from protein gels: in-gel deglycosylation followed by matrix-assisted laser desorption/ionization mass spectrometry and normal-phase high-performance…
A generally applicable, rapid, and sensitive method for profiling and sequencing of glycoprotein-associated N-linked oligosaccharides from protein gels was developed. The method employed sodium… Expand
  • 319
  • 13
Glycosylation differences between the normal and pathogenic prion protein isoforms.
  • P. Rudd, T. Endo, +8 authors R. Dwek
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 9 November 1999
Prion protein consists of an ensemble of glycosylated variants or glycoforms. The enzymes that direct oligosaccharide processing, and hence control the glycan profile for any given glycoprotein, are… Expand
  • 244
  • 13
  • PDF
Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG.
Ovarian cancer is the fourth most common cancer in women in the Western world. In a pilot scale study, we highlight changes in the total serum glycome of patients with advanced ovarian cancer that… Expand
  • 309
  • 12
Altered glycosylation pattern allows the distinction between prostate-specific antigen (PSA) from normal and tumor origins.
Prostate-specific antigen (PSA) is a glycoprotein secreted by prostate epithelial cells. PSA is currently used as a marker of prostate carcinoma because high levels of PSA are indicative of a tumor… Expand
  • 256
  • 12
Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity.
While the induction of a neutralizing antibody response against HIV remains a daunting goal, data from both natural infection and vaccine-induced immune responses suggest that it may be possible to… Expand
  • 229
  • 11
  • PDF
Complement regulation at the molecular level: the structure of decay-accelerating factor.
The human complement regulator CD55 is a key molecule protecting self-cells from complement-mediated lysis. X-ray diffraction and analytical ultracentrifugation data reveal a rod-like arrangement of… Expand
  • 107
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