Skip to search formSkip to main contentSkip to account menu
  • Publications
  • Influence
Principles of population genetics
Genetic and Phenotypic Variation Organisation of Genetic Variation Random Genetic Drift Mutation and the Neutral Theory Darwinian Selection Inbreeding, Population Subdivision, and Migration Molecular…
View via Publisher
Genetic applications of an inverse polymerase chain reaction.
TLDR
The feasibility of IPCR is shown by amplifying the sequences that flank an IS1 element in the genome of a natural isolate of Escherichia coli.
View on PubMed
A genome-wide view of the spectrum of spontaneous mutations in yeast
TLDR
The use of complete-genome sequencing in the characterization of spontaneously arising mutations in the yeast Saccharomyces cerevisiae yields numerous unexpected findings, in particular a very high rate of point mutation and skewed distribution of base-substitution types in the mitochondrion and segmental duplication and deletion in the nuclear genome.
View on Publisher
Mitochondrial pseudogenes: evolution's misplaced witnesses.
View on PubMed
Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins
TLDR
It is demonstrated that 102 mutational trajectories linking β-lactamase alleles are inaccessible to Darwinian selection and that many of the remaining trajectories have negligible probabilities of realization, which implies that the protein tape of life may be largely reproducible and even predictable.
View on Publisher
Sex-Dependent Gene Expression and Evolution of the Drosophila Transcriptome
TLDR
The results suggest that sex-dependent selection may drive changes in expression of many of the most rapidly evolving genes in the Drosophila transcriptome.
View on Publisher
Population genetics of polymorphism and divergence.
TLDR
The approach provides a theoretical basis for the use of a 2 x 2 contingency table to compare fixed differences and polymorphic sites with silent sites and amino acid replacements and suggests the estimate that the number of amino acids in the enzyme that are susceptible to favorable mutation is in the range 2-23 at any one time.
View on PubMed
A primer of population genetics
Part 1 Genetic variation: genetic and molecular essentials types of polymorphisms organization of genetic variation inbreeding. Part 2 The causes of evolution: mutation migration natural selection…
A Primer of Ecological Genetics
TLDR
Population genetics I: genetic variation, random and non-random mating, Population genetics II: changes in allele frequency, and Quantitative genetics I and II: advanced topics.
Missense meanderings in sequence space: a biophysical view of protein evolution
TLDR
This work reviews the literature on biophysics as it relates to molecular evolution and advances a biophysical model of protein evolution that helps to understand phenomena that range from the dynamics of molecular adaptation to the clock-like rate ofprotein evolution.
View on Springer
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License