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Common genetic determinants of vitamin D insufficiency: a genome-wide association study
Variants near genes involved in cholesterol synthesis, hydroxylation, and vitamin D transport affect vitamin D status, and genetic variation at these loci identifies individuals who have substantially raised risk of vitamin D insufficiency. Expand
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study
The combined effect of these risk alleles on fractures is similar to that of most well-replicated environmental risk factors, and they are present in more than one in five white people, suggesting a potential role in screening. Expand
The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study.
It is confirmed that excess body weight is a powerful predictor of OA of the knee in middle aged women, and a modest predictor of DIP and CMC OA. Expand
Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study.
Obesity and aging are associated with a high risk of new knee OA developing in women, and no clear association was found for incident JSN, suggesting that different etiologic mechanisms are operating or that standard radiographs are an inaccurate measure of incident narrowing. Expand
Risk of osteoarthritis associated with long-term weight-bearing sports: a radiologic survey of the hips and knees in female ex-athletes and population controls.
Weight-bearing sports activity in women is associated with a 2-3-fold increased risk of radiologic OA (particularly the presence of osteophytes) of the knees and hips, suggesting that duration rather than frequency of training is important. Expand
The association of body mass index and osteoarthritis of the knee joint: an examination of genetic and environmental influences.
The strong association between high BMI and knee OA is not likely to be mediated by shared genetic factors, and the results imply that environmental modification of BMI can influence knees OA. Expand
Genetic influences on osteoarthritis in women: a twin study
These results demonstrate for the first time a clear genetic effect for radiographic osteoarthritis of the hand and knee in women, with a genetic influence ranging from 39-65%, independent of known environmental or demographic confounders. Expand
The relationship between osteoarthritis and osteoporosis in the general population: the Chingford Study.
The results suggest that small increases in BMD are present in middle aged women with early radiological OA of the hands, knees and lumbar spine, and support the hypothesis that the two conditions are inversely related. Expand
Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women.
- T. Andrew, D. Hart, H. Snieder, M. de Lange, T. Spector, A. Macgregor
- Twin research : the official journal of the…
The results of twin studies can be generalised to singleton populations for these measures and disease outcomes, and volunteer twins were not found to differ from age-matched singleton women in distribution or prevalence. Expand
The association between hip morphology parameters and nineteen-year risk of end-stage osteoarthritis of the hip: A nested case–control study
Measurements are described that predict the risk of THA for end-stage OA by year 20, independently of the presence of radiographic hip OA at year 2, according to the alpha angle and lateral center edge angle. Expand