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Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors.
The tumor-killing properties of T cells provide tremendous opportunities to treat cancer. Adoptive T cell therapies have begun to harness this potential by endowing a functionally diverse repertoire… Expand
Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains
- D. Harris, Marlies V Hager, +8 authors D. Kranz
- Chemistry, Medicine
- The Journal of Immunology
- 1 February 2018
Adoptive T cell therapies have achieved significant clinical responses, especially in hematopoietic cancers. Two types of receptor systems have been used to redirect the activity of T cells, normal… Expand
TCR affinity for p/MHC formed by tumor antigens that are self-proteins: impact on efficacy and toxicity.
Recent studies have shown that the range of affinities of T cell receptors (TCRs) against non-mutated cancer peptide/class I complexes are lower than TCR affinities for foreign antigens. Raising the… Expand
A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor control
- J. Stone, D. Harris, +4 authors D. Kranz
- Biology, Medicine
- Cancer Immunology, Immunotherapy
- 1 August 2014
Adoptive transfer of genetically modified T cells to treat cancer has shown promise in several clinical trials. Two main strategies have been applied to redirect T cells against cancer: (1)… Expand
The C11R Gene, Which Encodes the Vaccinia Virus Growth Factor, Is Partially Responsible for MVA-Induced NF-κB and ERK2 Activation
ABSTRACT MVA is an attenuated strain of vaccinia virus (VACV) that is a popular vaccine vector. MVA infection activates NF-κB. For 293T cells, it is known that MVA early gene expression activates… Expand
Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex*
- D. Harris, Ningyan Wang, +5 authors D. Kranz
- Biology, Medicine
- The Journal of Biological Chemistry
- 28 September 2016
Proteins are often engineered to have higher affinity for their ligands to achieve therapeutic benefit. For example, many studies have used phage or yeast display libraries of mutants within… Expand
An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.
Utilizing a diverse binding site, T cell receptors (TCRs) specifically recognize a composite ligand comprised of a foreign peptide and a major histocompatibility complex protein (MHC). To help… Expand
T Cell Receptor Engineering and Analysis Using the Yeast Display Platform.
The αβ heterodimeric T cell receptor (TCR) recognizes peptide antigens that are transported to the cell surface as a complex with a protein encoded by the major histocompatibility complex (MHC). T… Expand
T-cell Receptors Engineered De Novo for Peptide Specificity Can Mediate Optimal T-cell Activity without Self Cross-Reactivity
- P. Sharma, D. Harris, J. Stone, D. Kranz
- Medicine, Chemistry
- Cancer Immunology Research
- 23 September 2019
Cancer antigen–specific TCRs generated by directed evolution provide an alternative for adoptive T-cell therapies. A TCR generated by molecular evolution showed similar specificity and less… Expand
An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes.
T cell receptors (TCRs) orchestrate cellular immunity by recognizing peptides presented by a range of major histocompatibility complex (MHC) proteins. Naturally occurring TCRs bind the composite… Expand