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Glutamate Transporter Coupling to Na,K-ATPase
Findings demonstrate that glutamate transporters and Na,K-ATPases are part of the same macromolecular complexes and operate as a functional unit to regulate glutamatergic neurotransmission.
Impaired Cerebellar Synaptic Plasticity and Motor Performance in Mice Lacking the mGluR4 Subtype of Metabotropic Glutamate Receptor
The results indicate that an important function of mGluR4 is to provide a presynaptic mechanism for maintaining synaptic efficacy during repetitive activation, and suggest that the presence ofmGLUR4 at the parallel fiber→Purkinje cell synapse is required for maintaining normal motor function.
Cloning and characterization of a Family C orphan G‐protein coupled receptor
Findings suggest that GPRC6A may function as the receptor component of a novel cellular transmitter system in mammals.
Activation of Family C G-protein-coupled Receptors by the Tripeptide Glutathione*
A potential new role for GSH is revealed and this peptide may act as an endogenous modulator of the CaSR in the parathyroid gland, and in other tissues such as the brain and gastrointestinal tract where the role of the calcium receptor appears to subserve other, as yet unknown, physiological functions.
Phosphorylation and modulation of a kainate receptor (GluR6) by cAMP-dependent protein kinase.
Results indicate that glutamate receptor function can be directly modulated by protein phosphorylation and suggest that a dynamic regulation of excitatory receptors could be associated with some forms of learning and memory in the mammalian brain.
Autism spectrum disorders and neuropathology of the cerebellum
Advances in research on idiopathic autism and three genetic forms of autism that highlight the key roles that the cerebellum plays in this spectrum of neurodevelopmental disorders are summarized.
Molecular Similarities in the Ligand Binding Pockets of an Odorant Receptor and the Metabotropic Glutamate Receptors*
The essential features of amino acid selectivity within the 5.24 receptor binding pocket are defined and an evolutionarily conserved motif required for ligand recognition in amino acid activated receptors in the G-protein-coupled receptor superfamily is highlighted.