Chemokines and Glycoprotein120 Produce Pain Hypersensitivity by Directly Exciting Primary Nociceptive Neurons
- S. Oh, P. Tran, S. Gillard, R. Hurley, D. Hammond, R. Miller
- Biology, MedicineJournal of Neuroscience
- 15 July 2001
Evidence is provided that chemokines and gp120 may produce painful effects via direct actions on chemokine receptors expressed by nociceptive neurons in rats associated with HIV-1 infection and inflammation.
Chloride regulation in the pain pathway
- Theodore John Price, F. Cerveró, M. Gold, D. Hammond, S. Prescott
- BiologyBrain Research Reviews
- 1 April 2009
Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation
- B. T. Aldrich, E. Frakes, J. Kasuya, D. Hammond, T. Kitamoto
- BiologyNeuroscience
- 1 December 2009
Effects of spinal nerve ligation on immunohistochemically identified neurons in the L4 and L5 dorsal root ganglia of the rat
- D. Hammond, Laura C. Ackerman, R. Holdsworth, B. Elzey
- BiologyThe Journal of comparative neurology
- 2 August 2004
A significant decrease in the numbers of large‐sized neurons is revealed, coupled with an increase in the number of small‐ to medium‐sized cells, and the appearance of a novel population of very small‐sized neuron labeled by N52 is revealed.
The analgesic effects of supraspinal mu and delta opioid receptor agonists are potentiated during persistent inflammation.
- R. Hurley, D. Hammond
- BiologyJournal of Neuroscience
- 2000
Results indicate that peripheral inflammatory injury alters the pharmacology of excitatory and inhibitory inputs that modulate the activity of RVM neurons in such a manner as to enhance the effects of opioid agonists in this region.
Efflux of 5‐hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla.
- D. Hammond, G. Tyce, T. Yaksh
- BiologyJournal of Physiology
- 1 February 1985
The ability of stimulation at these sites to evoke the spinal release of the probable neurotransmitters further supports the hypothesis that the antinociceptive effect is mediated by activation of serotonergic and noradrenergic neurones projecting to the spinal cord.
Morphine or U‐50,488 suppresses fos protein‐like immunoreactivity in the spinal cord and nucleus tractus solitarii evoked by a noxious visceral stimulus in the rat
- D. Hammond, R. Presley, K. Gogas, A. Basbaum
- BiologyThe Journal of comparative neurology
- 8 January 1992
It is suggested that morphine and U‐50,488 have comparable effects on the transmission of visceral nociceptive messages by spinal neurons, but differentially affect the autonomic response to noxious visceral stimuli.
Electrophysiological heterogeneity of spinally projecting serotonergic and nonserotonergic neurons in the rostral ventromedial medulla.
- Liang Zhang, K. T. Sykes, A. Buhler, D. Hammond
- BiologyJournal of Neurophysiology
- 1 March 2006
Results provide important new electrophysiological and pharmacological evidence for a significant heterogeneity among spinally projecting serotonergic RVM neurons and may provide a basis for resolving the controversy concerning the role of serotonerg R VM neurons in opioid analgesia.
Antagonism of stimulation-produced antinociception by intrathecal administration of methysergide or phentolamine
- D. Hammond, T. Yaksh
- BiologyBrain Research
- 30 April 1984
The Analgesic Effects of Supraspinal μ and δ Opioid Receptor Agonists Are Potentiated during Persistent Inflammation
- R. Hurley, D. Hammond
- BiologyJournal of Neuroscience
- 1 February 2000
Results indicate that peripheral inflammatory injury alters the pharmacology of excitatory and inhibitory inputs that modulate the activity of RVM neurons in such a manner as to enhance the effects of opioid agonists in this region.
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