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Tensional homeostasis and the malignant phenotype.
TLDR
It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation. Expand
The reaction-limited kinetics of membrane-to-surface adhesion and detachment
TLDR
A set of constitutive laws relating bond stress to bond strain and also relating the chemical rate constants of the adhesion molecules to Bond strain are proposed and an exact formula for the critical tension is derived. Expand
Polymersomes: tough vesicles made from diblock copolymers.
TLDR
The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry, and both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements. Expand
Simulation of cell rolling and adhesion on surfaces in shear flow: general results and analysis of selectin-mediated neutrophil adhesion.
The receptor-mediated adhesion of cells to ligand-coated surfaces in viscous shear flow is an important step in many physiological processes, such as the neutrophil-mediated inflammatory response,Expand
Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow
TLDR
It is reported here that transient tethers had first-order kinetics and other characteristics suggesting a unimolecular interaction between P-selectin and its glycoprotein ligand (PSGL-1) and fast on and off rates appear necessary to support rolling at physiological shear stresses. Expand
The dynamics and mechanics of endothelial cell spreading.
TLDR
This study is the first to monitor the dynamic changes in the cell shape, spreading rate, and forces exerted during the early stages (first several hours) of endothelial cell adhesion. Expand
A microcantilever device to assess the effect of force on the lifetime of selectin-carbohydrate bonds.
TLDR
A microcantilever technique was used to apply force to receptor-ligand molecules involved in leukocyte rolling on blood vessel walls, implying that >80% of adhesive events involve single bonds. Expand
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
TLDR
A bulky glycocalyx is a feature of tumour cells that could foster metastasis by mechanically enhancing cell-surface receptor function by increasing integrin adhesion and signalling. Expand
Cell-cell mechanical communication through compliant substrates.
TLDR
This work finds that cells can detect and respond to substrate strains created by the traction stresses of a neighboring cell, and that this response is dependent on matrix stiffness, and indicates that cells have the ability to communicate mechanically through their matrix. Expand
Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow
SELECTINS tether to the blood vessel wall leukocytes that are flowing in the bloodstream and support subsequent labile rolling interactions as the leukocytes are subjected to hydrodynamic dragExpand
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